Difference between revisions of "Low-grade oncocytic renal tumour"

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Low-grade oncocytic renal tumour (view source)

Revision as of 16:03, 21 February 2024

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| LMDDx      = [[renal oncocytoma]], [[chromophobe renal cell carcinoma]] eosinophilic variant, [[clear cell renal cell carcinoma]] eosinophilic variant, [[papillary renal cell carcinoma]] oncocytic variant, [[tubulocystic carcinoma of the kidney]], other [[renal tumours with eosinophilic cytoplasm]], benign [[liver]]
| LMDDx      = [[renal oncocytoma]], [[chromophobe renal cell carcinoma]] eosinophilic variant, [[clear cell renal cell carcinoma]] eosinophilic variant, [[papillary renal cell carcinoma]] oncocytic variant, [[tubulocystic carcinoma of the kidney]], other [[renal tumours with eosinophilic cytoplasm]], benign [[liver]]
| Stains    =  
| Stains    =  
| IHC        = CK7 +ve, CD117 -ve, [[PAX8]] +ve, GATA3 +ve  
| IHC        = CK7 +ve, CD117 -ve, GATA3 +ve, [[PAX8]] +ve
| EM        =  
| EM        =  
| Molecular  =
| Molecular  =
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*CK7 +ve.
*CK7 +ve.
*[[GATA3]] +ve.
*[[GATA3]] +ve.
**Very rarely positive in RCCs (1/71 clear cell RCC, 0/53 papillary RCC, 2/33 chromophobe RCC).<ref name=pmid2431520>{{cite journal |authors=Gonzalez-Roibon N, Faraj SF, Munari E, Bezerra SM, Albadine R, Sharma R, Argani P, Allaf ME, Netto GJ |title=Comprehensive profile of GATA binding protein 3 immunohistochemical expression in primary and metastatic renal neoplasms |journal=Hum Pathol |volume=45 |issue=2 |pages=244–8 |date=February 2014 |pmid=24315206 |doi=10.1016/j.humpath.2013.08.020 |url=}}</ref>
**GATA3 very rarely positive in RCCs (1/71 clear cell RCC, 0/53 papillary RCC, 2/33 chromophobe RCC).<ref name=pmid2431520>{{cite journal |authors=Gonzalez-Roibon N, Faraj SF, Munari E, Bezerra SM, Albadine R, Sharma R, Argani P, Allaf ME, Netto GJ |title=Comprehensive profile of GATA binding protein 3 immunohistochemical expression in primary and metastatic renal neoplasms |journal=Hum Pathol |volume=45 |issue=2 |pages=244–8 |date=February 2014 |pmid=24315206 |doi=10.1016/j.humpath.2013.08.020 |url=}}</ref>
**May be positive in oncocytoma (9/47 cases).<ref name=pmid2431520/>
**GATA3 occasionally positive in oncocytoma (9/47 cases).<ref name=pmid2431520/>
*PAX8 +ve.
*PAX8 +ve.
*CD117 -ve.
*CD117 -ve.
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Comment:
Comment:
The tumour stains as follows:
The tumour stains as follows:
POSITIVE: CK7 (strong, diffuse), CD117 (very focal), PAX8 (strong, diffuse), AE1/AE3, AMACR, E-cadherin, BerEP4.
POSITIVE: CK7 (strong, diffuse), PAX8 (strong, diffuse), AE1/AE3, GATA-3 (moderate, diffuse).
NEGATIVE: CD10, CK20, vimentin, CA9.
NEGATIVE: CD117, CD10, CK20, vimentin, CA9.


This tumour does not completely fit the diagnosis of renal oncocytoma or eosinophilic chromophobe renal cell carcinoma.  
It is in keeping with "low-grade oncocytic tumour" (LOT), an evolving entity. Based on limited data, LOT appears to have an indolent behavior. 


It is in keeping with "low-grade oncocytic tumour" (LOT), an evolving entity. Based on limited data, LOT appears to have an indolent behavior.
This tumour does not fit the diagnosis of renal oncocytoma or eosinophilic chromophobe renal cell carcinoma.  
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