Difference between revisions of "Loop electrosurgical excision procedure"

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COMMENT:
COMMENT:
In the context of the previous pap tests and endocervical curettage, no additional  
In the context of the preceding pap tests and endocervical curettage, no additional  
levels were cut on the LEEP specimen.
levels were cut on the LEEP specimen.
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Revision as of 14:08, 7 December 2013

Loop electrosurgical excision procedure, abbreviated LEEP, is a gynecologic procedure to remove tissue from the uterine cervix.[1] It is used to diagnose, stage and treat cervical neoplasia.

Negative LEEP

Definition

Prevalence

  • Relatively common ~ 25% of cases in one larger series.[2]

Work-up

  1. Review the biopsy that triggered the LEEP - check whether it is HSIL.
  2. Cut levels (x3) on all blocks.
  3. Flip all the blocks and cut levels (x3) on all the blocks.
  4. Do a p16 immunostain on the most suspicious block, if the triggering diagnosis was cannot exclude HSIL, HSIL or SCC.
  5. Sign out the thing as negative - see below.

Sign out

A. UTERINE CERVIX, LOOP ELECTROSURGICAL EXCISION PROCEDURE (LEEP):
- ACUTE AND CHRONIC CERVICITIS.
- BENIGN SQUAMOUS EPITHELIUM, METAPLASTIC SQUAMOUS EPITHELIUM, AND BENIGN
  ENDOCERVICAL GLANDS.
- NEGATIVE FOR DYSPLASIA AND NEGATIVE FOR MALIGNANCY, SEE COMMENT.

B. UTERINE ENDOCERVIX, CURETTAGE:
- ENDOCERVICAL MUCOSA AND STRIPPED ENDOCERVICAL EPITHELIUM WITHIN NORMAL LIMITS.
- BENIGN SQUAMOUS EPITHELIUM.
- NEGATIVE FOR DYSPLASIA.

COMMENT:
Levels were cut (x3) on all blocks. The blocks were then flipped and an 
additional set of levels (x3) were cut on all blocks.

A p16 immunostain was done on A1. It does not demonstrate 
high-grade dysplasia.

The previous pathology was partially reviewed, and I have no significant
disagreement with the findings.

Not indicated

COMMENT:
In the context of the preceding pap tests and endocervical curettage, no additional 
levels were cut on the LEEP specimen.

See also

References

  1. URL: http://www.webmd.com/cancer/cervical-cancer/loop-electrosurgical-excision-procedure-leep-for-abnormal-cervical-cell-changes. Accessed on: 13 August 2012.
  2. 2.0 2.1 Witt, BL.; Factor, RE.; Jarboe, EA.; Layfield, LJ. (Oct 2012). "Negative loop electrosurgical cone biopsy finding following a biopsy diagnosis of high-grade squamous intraepithelial lesion: frequency and clinical significance.". Arch Pathol Lab Med 136 (10): 1259-61. doi:10.5858/arpa.2011-0494-OA. PMID 23020732.