Difference between revisions of "Long-term epilepsy associated tumor"

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==General==
==General==
* Closely associated with [[Ganglioglioma]] and [[DNT]].
* Closely associated with [[Ganglioglioma]] and [[DNT]].
* Poor interobserver agreement. <ref name="pmid30326153">{{cite journal |vauthors=Blümcke I, Coras R, Wefers AK, Capper D, Aronica E, Becker A, Honavar M, Stone TJ, Jacques TS, Miyata H, Mühlebner A, Pimentel J, Söylemezoğlu F, Thom M |title=Review: Challenges in the histopathological classification of ganglioglioma and DNT: microscopic agreement studies and a preliminary genotype-phenotype analysis |journal=Neuropathol Appl Neurobiol |volume=45 |issue=2 |pages=95–107 |date=February 2019 |pmid=30326153 |doi=10.1111/nan.12522 |url=}}</ref>
* Poor interobserver agreement. <ref name="pmid30326153">{{cite journal |authors=Blümcke I, Coras R, Wefers AK, Capper D, Aronica E, Becker A, Honavar M, Stone TJ, Jacques TS, Miyata H, Mühlebner A, Pimentel J, Söylemezoğlu F, Thom M |title=Review: Challenges in the histopathological classification of ganglioglioma and DNT: microscopic agreement studies and a preliminary genotype-phenotype analysis |journal=Neuropathol Appl Neurobiol |volume=45 |issue=2 |pages=95–107 |date=February 2019 |pmid=30326153 |doi=10.1111/nan.12522 |url=}}</ref>
* Some entities can be molecularly defined.<ref name="pmid30759284">{{cite journal |vauthors=Hou Y, Pinheiro J, Sahm F, Reuss DE, Schrimpf D, Stichel D, Casalini B, Koelsche C, Sievers P, Wefers AK, Reinhardt A, Ebrahimi A, Fernández-Klett F, Pusch S, Meier J, Schweizer L, Paulus W, Prinz M, Hartmann C, Plate KH, Reifenberger G, Pietsch T, Varlet P, Pagès M, Schüller U, Scheie D, de Stricker K, Frank S, Hench J, Pollo B, Brandner S, Unterberg A, Pfister SM, Jones DTW, Korshunov A, Wick W, Capper D, Blümcke I, von Deimling A, Bertero L |title=Papillary glioneuronal tumor (PGNT) exhibits a characteristic methylation profile and fusions involving PRKCA |journal=Acta Neuropathol |volume=137 |issue=5 |pages=837–846 |date=May 2019 |pmid=30759284 |doi=10.1007/s00401-019-01969-2 |url=}}</ref> - but some not.
* Some entities can be molecularly defined.<ref name="pmid30759284">{{cite journal |authors=Hou Y, Pinheiro J, Sahm F, Reuss DE, Schrimpf D, Stichel D, Casalini B, Koelsche C, Sievers P, Wefers AK, Reinhardt A, Ebrahimi A, Fernández-Klett F, Pusch S, Meier J, Schweizer L, Paulus W, Prinz M, Hartmann C, Plate KH, Reifenberger G, Pietsch T, Varlet P, Pagès M, Schüller U, Scheie D, de Stricker K, Frank S, Hench J, Pollo B, Brandner S, Unterberg A, Pfister SM, Jones DTW, Korshunov A, Wick W, Capper D, Blümcke I, von Deimling A, Bertero L |title=Papillary glioneuronal tumor (PGNT) exhibits a characteristic methylation profile and fusions involving PRKCA |journal=Acta Neuropathol |volume=137 |issue=5 |pages=837–846 |date=May 2019 |pmid=30759284 |doi=10.1007/s00401-019-01969-2 |url=}}</ref> - but some not.


==Examples==
==Examples==
* Papillary glioneuronal tumor <ref name="pmid23173837">{{cite journal |vauthors=Demetriades AK, Al Hyassat S, Al-Sarraj S, Bhangoo RS, Ashkan K |title=Papillary glioneuronal tumour: a review of the literature with two illustrative cases |journal=Br J Neurosurg |volume=27 |issue=3 |pages=401–4 |date=June 2013 |pmid=23173837 |doi=10.3109/02688697.2012.741735 |url=}}</ref>
* Papillary glioneuronal tumor <ref name="pmid23173837">{{cite journal |authors=Demetriades AK, Al Hyassat S, Al-Sarraj S, Bhangoo RS, Ashkan K |title=Papillary glioneuronal tumour: a review of the literature with two illustrative cases |journal=Br J Neurosurg |volume=27 |issue=3 |pages=401–4 |date=June 2013 |pmid=23173837 |doi=10.3109/02688697.2012.741735 |url=}}</ref>
* [[Angiocentric glioma]] <ref name="pmid26948368">{{cite journal |vauthors=Soffietti R, Rudà R, Reardon D |title=Rare glial tumors |journal=Handb Clin Neurol |volume=134 |issue= |pages=399–415 |date=2016 |pmid=26948368 |doi=10.1016/B978-0-12-802997-8.00024-4 |url=}}</ref>
* [[Angiocentric glioma]] <ref name="pmid26948368">{{cite journal |authors=Soffietti R, Rudà R, Reardon D |title=Rare glial tumors |journal=Handb Clin Neurol |volume=134 |issue= |pages=399–415 |date=2016 |pmid=26948368 |doi=10.1016/B978-0-12-802997-8.00024-4 |url=}}</ref>
* Isomorphic diffuse glioma <ref name="pmid31563982">{{cite journal |vauthors=Wefers AK, Stichel D, Schrimpf D, Coras R, Pages M, Tauziède-Espariat A, Varlet P, Schwarz D, Söylemezoglu F, Pohl U, Pimentel J, Meyer J, Hewer E, Japp A, Joshi A, Reuss DE, Reinhardt A, Sievers P, Casalini MB, Ebrahimi A, Huang K, Koelsche C, Low HL, Rebelo O, Marnoto D, Becker AJ, Staszewski O, Mittelbronn M, Hasselblatt M, Schittenhelm J, Cheesman E, de Oliveira RS, Queiroz RGP, Valera ET, Hans VH, Korshunov A, Olar A, Ligon KL, Pfister SM, Jaunmuktane Z, Brandner S, Tatevossian RG, Ellison DW, Jacques TS, Honavar M, Aronica E, Thom M, Sahm F, von Deimling A, Jones DTW, Blumcke I, Capper D |title=Isomorphic diffuse glioma is a morphologically and molecularly distinct tumour entity with recurrent gene fusions of MYBL1 or MYB and a benign disease course |journal=Acta Neuropathol |volume=139 |issue=1 |pages=193–209 |date=January 2020 |pmid=31563982 |pmc=7477753 |doi=10.1007/s00401-019-02078-w |url=}}</ref>
* Isomorphic diffuse glioma <ref name="pmid31563982">{{cite journal |authors=Wefers AK, Stichel D, Schrimpf D, Coras R, Pages M, Tauziède-Espariat A, Varlet P, Schwarz D, Söylemezoglu F, Pohl U, Pimentel J, Meyer J, Hewer E, Japp A, Joshi A, Reuss DE, Reinhardt A, Sievers P, Casalini MB, Ebrahimi A, Huang K, Koelsche C, Low HL, Rebelo O, Marnoto D, Becker AJ, Staszewski O, Mittelbronn M, Hasselblatt M, Schittenhelm J, Cheesman E, de Oliveira RS, Queiroz RGP, Valera ET, Hans VH, Korshunov A, Olar A, Ligon KL, Pfister SM, Jaunmuktane Z, Brandner S, Tatevossian RG, Ellison DW, Jacques TS, Honavar M, Aronica E, Thom M, Sahm F, von Deimling A, Jones DTW, Blumcke I, Capper D |title=Isomorphic diffuse glioma is a morphologically and molecularly distinct tumour entity with recurrent gene fusions of MYBL1 or MYB and a benign disease course |journal=Acta Neuropathol |volume=139 |issue=1 |pages=193–209 |date=January 2020 |pmid=31563982 |pmc=7477753 |doi=10.1007/s00401-019-02078-w |url=}}</ref>
* Multinodular and vacuolating neuronal tumor of the cerebrum <ref name="pmid32979644">{{cite journal |vauthors=Alizada O, Ayman T, Akgun MY, Sar M, Urganci N, Kemerdere R |title=Multinodular and vacuolating neuronal tumor of the cerebrum: Two cases and review of the literature |journal=Clin Neurol Neurosurg |volume=197 |issue= |pages=106149 |date=October 2020 |pmid=32979644 |doi=10.1016/j.clineuro.2020.106149 |url=}}</ref>
* Multinodular and vacuolating neuronal tumor of the cerebrum <ref name="pmid32979644">{{cite journal |authors=Alizada O, Ayman T, Akgun MY, Sar M, Urganci N, Kemerdere R |title=Multinodular and vacuolating neuronal tumor of the cerebrum: Two cases and review of the literature |journal=Clin Neurol Neurosurg |volume=197 |issue= |pages=106149 |date=October 2020 |pmid=32979644 |doi=10.1016/j.clineuro.2020.106149 |url=}}</ref>
* Polymorphous low grade tumor of the young <ref name="pmid27812792">{{cite journal |vauthors=Huse JT, Snuderl M, Jones DT, Brathwaite CD, Altman N, Lavi E, Saffery R, Sexton-Oates A, Blumcke I, Capper D, Karajannis MA, Benayed R, Chavez L, Thomas C, Serrano J, Borsu L, Ladanyi M, Rosenblum MK |title=Polymorphous low-grade neuroepithelial tumor of the young (PLNTY): an epileptogenic neoplasm with oligodendroglioma-like components, aberrant CD34 expression, and genetic alterations involving the MAP kinase pathway |journal=Acta Neuropathol |volume=133 |issue=3 |pages=417–429 |date=March 2017 |pmid=27812792 |pmc=5325850 |doi=10.1007/s00401-016-1639-9 |url=}}</ref>
* Polymorphous low grade tumor of the young <ref name="pmid27812792">{{cite journal |authors=Huse JT, Snuderl M, Jones DT, Brathwaite CD, Altman N, Lavi E, Saffery R, Sexton-Oates A, Blumcke I, Capper D, Karajannis MA, Benayed R, Chavez L, Thomas C, Serrano J, Borsu L, Ladanyi M, Rosenblum MK |title=Polymorphous low-grade neuroepithelial tumor of the young (PLNTY): an epileptogenic neoplasm with oligodendroglioma-like components, aberrant CD34 expression, and genetic alterations involving the MAP kinase pathway |journal=Acta Neuropathol |volume=133 |issue=3 |pages=417–429 |date=March 2017 |pmid=27812792 |pmc=5325850 |doi=10.1007/s00401-016-1639-9 |url=}}</ref>




==Criteria==
==Criteria==
See <ref name="pmid32151273">{{cite journal |vauthors=Slegers RJ, Blumcke I |title=Low-grade developmental and epilepsy associated brain tumors: a critical update 2020 |journal=Acta Neuropathol Commun |volume=8 |issue=1 |pages=27 |date=March 2020 |pmid=32151273 |pmc=7063704 |doi=10.1186/s40478-020-00904-x |url=}}</ref>
See <ref name="pmid32151273">{{cite journal |authors=Slegers RJ, Blumcke I |title=Low-grade developmental and epilepsy associated brain tumors: a critical update 2020 |journal=Acta Neuropathol Commun |volume=8 |issue=1 |pages=27 |date=March 2020 |pmid=32151273 |pmc=7063704 |doi=10.1186/s40478-020-00904-x |url=}}</ref>
* Seizures <18 years.
* Seizures <18 years.
* Temporal lobe location.
* Temporal lobe location.
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