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Difference between revisions of "Liver pathology"
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**Similar to trichrome. | **Similar to trichrome. | ||
Common IHC:<ref name= | Common IHC:<ref name=ap27may2009>Pollet, A. 27 May 2009.</ref> | ||
*CK7 - bile ducts, and bile ductules +ve. | *CK7 - bile ducts, and bile ductules +ve. | ||
*CD34 - should be -ve in normal liver. | *CD34 - should be -ve in normal liver. | ||
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*'''Not''' related to ''[[bile duct adenoma]]''. | *'''Not''' related to ''[[bile duct adenoma]]''. | ||
Images: | ====Images==== | ||
<gallery> | |||
Image:Von_Meyenburg_complex_low_mag.jpg | Von Meyenburg complex - bile duct hamartoma (WC) | |||
Image:Bile_duct_hamartoma_intermed_mag.jpg | Bile duct hamartoma - intermed. mag. (WC) | |||
</gallery> | |||
www: | |||
*[http://radiographics.rsna.org/content/25/3/659/F7.expansion.html Bile duct hamartoma - gross image (rsna.org)]. | *[http://radiographics.rsna.org/content/25/3/659/F7.expansion.html Bile duct hamartoma - gross image (rsna.org)]. | ||
*[http://radiographics.rsna.org/content/25/3/659/F8.expansion.html Bile duct hamartoma (rsna.org)]. | *[http://radiographics.rsna.org/content/25/3/659/F8.expansion.html Bile duct hamartoma (rsna.org)]. | ||
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**It is usually periportal. | **It is usually periportal. | ||
Images | ====Images==== | ||
<gallery> | |||
Image:Ballooning_degeneration_high_mag_cropped.jpg | Ballooning degeneration. (WC/Nephron) | |||
</gallery> | |||
www: | |||
*[http://www.uthscsa.edu/hscnews/EnlargePicture.asp?PicName=LiverBeforeTreatment_BODY.jpg Ballooning degeneration (uthscsa.edu)]. | *[http://www.uthscsa.edu/hscnews/EnlargePicture.asp?PicName=LiverBeforeTreatment_BODY.jpg Ballooning degeneration (uthscsa.edu)]. | ||
*[http://library.med.utah.edu/WebPath/LIVEHTML/LIVER039.html Ballooning degeneration (med.utah.edu)]. | *[http://library.med.utah.edu/WebPath/LIVEHTML/LIVER039.html Ballooning degeneration (med.utah.edu)]. | ||
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Micrographs of GGHs: | Micrographs of GGHs: | ||
<gallery> | |||
Image:Ground_glass_hepatocytes_high_mag_cropped.jpg | Ground glass hepatocyte. (WC/Nephron) | |||
</gallery> | |||
www: | |||
*[http://www.consultantlive.com/aids/article/1145619/1363027 Ground glass hepatocytes (consultantlive.com)]. | *[http://www.consultantlive.com/aids/article/1145619/1363027 Ground glass hepatocytes (consultantlive.com)]. | ||
*[http://www.biomedcentral.com/1471-230X/5/36/figure/F1 Ground glass hepatocytes (biomedcentral.com)]. | *[http://www.biomedcentral.com/1471-230X/5/36/figure/F1 Ground glass hepatocytes (biomedcentral.com)]. | ||
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|} | |} | ||
====Images==== | |||
<gallery> | |||
Image:Mallory_body_high_mag_cropped.jpg | Mallory body. (WC/Nephron) | |||
</gallery> | |||
www: | |||
*[http://en.wikipedia.org/wiki/File:CDC_mallory_bodies.jpg Mallory bodies - CDC/WP (WP)]. | *[http://en.wikipedia.org/wiki/File:CDC_mallory_bodies.jpg Mallory bodies - CDC/WP (WP)]. | ||
*[http://www.nature.com/modpathol/journal/v20/n1s/fig_tab/3800682f6.html Mallory bodies - Mod. Pathol. (nature.com)]. | *[http://www.nature.com/modpathol/journal/v20/n1s/fig_tab/3800682f6.html Mallory bodies - Mod. Pathol. (nature.com)]. | ||
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***Small, shrunken, pale staining. | ***Small, shrunken, pale staining. | ||
**Eosinophilic cytoplasm. | **Eosinophilic cytoplasm. | ||
Notes: | Notes: | ||
*[[AKA]] ''Councilman-like bodies''; see ''notes'' in ''Councilman bodies'' below. | *[[AKA]] ''Councilman-like bodies''; see ''notes'' in ''Councilman bodies'' below. | ||
====Image==== | |||
<gallery> | |||
Image:Ballooning_degeneration_high_mag_cropped.jpg | Councilman body - high mag. (WC) | |||
</gallery> | |||
===Councilman bodies=== | ===Councilman bodies=== | ||
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Images: | Images: | ||
*[http://www.meddean.luc.edu/lumen/MedEd/orfpath/cirhosis.htm Cirrhosis - macronodular & micronodular (meddean.luc.edu)]. | *[http://www.meddean.luc.edu/lumen/MedEd/orfpath/cirhosis.htm Cirrhosis - macronodular & micronodular (meddean.luc.edu)]. | ||
<gallery> | |||
Image:Cirrhosis_high_mag.jpg | Cirrhotic liver - trichrome stain. (WC/Nephron) | |||
</gallery> | |||
===Steatosis of the liver=== | ===Steatosis of the liver=== | ||
Can be divided into: | Can be divided into: | ||
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*Alcoholic liver disease, alcoholic steatohepatitis (ASH). | *Alcoholic liver disease, alcoholic steatohepatitis (ASH). | ||
Image: | Image: | ||
<gallery> | |||
Image:Non-alcoholic_fatty_liver_disease1.jpg | Centrilobular steatosis. (WC/Nephron) | |||
</gallery> | |||
Periportal predominant (zone I) - ''TAPES'':<ref name=pcddx_steatosis/> | Periportal predominant (zone I) - ''TAPES'':<ref name=pcddx_steatosis/> | ||
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**More than 30% means the liver is undesirable for [[Liver transplantation pathology|transplantation]].<ref>STC. 6 December 2010.</ref> | **More than 30% means the liver is undesirable for [[Liver transplantation pathology|transplantation]].<ref>STC. 6 December 2010.</ref> | ||
Image: | Image: | ||
<gallery> | |||
Image:Periportal_hepatosteatosis_intermed_mag.jpg | Periportal steatosis (WC/Nephron) | |||
</gallery> | |||
===Cholestasis=== | ===Cholestasis=== | ||
====General==== | ====General==== | ||
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*Abnormal liver plate architecture. (???) | *Abnormal liver plate architecture. (???) | ||
Images | ======Images====== | ||
<gallery> | |||
Image:Cholestasis_high_mag.jpg | Cholestasis. (WC/Nephron) | |||
</gallery> | |||
www: | |||
*[http://www.humpath.com/spip.php?article4340&id_document=20040 Centrilobular cholestasis (humpath.com)]. | *[http://www.humpath.com/spip.php?article4340&id_document=20040 Centrilobular cholestasis (humpath.com)]. | ||