Difference between revisions of "Littoral cell angioma"

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{{ Infobox diagnosis
{{ Infobox diagnosis
| Name      = {{PAGENAME}}
| Name      = {{PAGENAME}}
| Image      =  
| Image      = Littoral_cell_angioma_of_the_spleen_-_low_mag.jpg
| Width      =
| Width      =
| Caption    =  
| Caption    = Littoral cell angioma. [[H&E stain]].
| Synonyms  =
| Synonyms  =
| Micro      =
| Micro      = anastoming, small vascular channels, cystic spaces - may have papillary projections
| Subtypes  =
| Subtypes  =
| LMDDx      = [[hemangioendothelioma]], [[angiosarcoma]], [[hemangiopericytoma]], [[splenic hamartoma]]
| LMDDx      = [[hemangioendothelioma]], [[angiosarcoma]], [[hemangiopericytoma]], [[splenic hamartoma]]
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| Assdx      =
| Assdx      =
| Syndromes  =
| Syndromes  =
| Clinicalhx =
| Clinicalhx = weight loss
| Signs      =
| Signs      = pyrexia (fever), splenomegaly
| Symptoms  =
| Symptoms  =
| Prevalence = rare
| Prevalence = rare
| Bloodwork  =
| Bloodwork  =
| Rads      =
| Rads      = solitary hypodense lesion
| Endoscopy  =
| Endoscopy  =
| Prognosis  = benign
| Prognosis  = benign

Revision as of 21:24, 16 February 2014

Littoral cell angioma
Diagnosis in short

Littoral cell angioma. H&E stain.

LM anastoming, small vascular channels, cystic spaces - may have papillary projections
LM DDx hemangioendothelioma, angiosarcoma, hemangiopericytoma, splenic hamartoma
Site spleen

Clinical history weight loss
Signs pyrexia (fever), splenomegaly
Prevalence rare
Radiology solitary hypodense lesion
Prognosis benign

Littoral cell angioma, abbreviated LCA, is an uncommon benign vascular lesion of the spleen.

Angioma, in general, is dealt with in vascular malformations.

General

Features:[1]

  • Rare.
  • Benign.

Clinical:[1][2]

  • Pyrexia (fever), splenomegaly, weight loss, solitary hypodense lesion on imaging.

Note:

  • Littoral cells = line vascular channels of the red pulp.[1]
    • Littoral = related to shore.[3][4]

Microscopic

Features:[1]

  • Anastoming, small vascular channels.
  • Cystic spaces.
    • May have papillary projections.[2]

DDx:[1]

Images

www:

IHC

Features:[1]

  • CD68 +ve.
  • CD31 +ve

Others:

  • CD34 -ve.
  • Factor VIII +ve.

See also

References

  1. 1.0 1.1 1.2 1.3 1.4 1.5 Tan, YM.; Chuah, KL.; Wong, WK. (Jul 2004). "Littoral cell angioma of the spleen.". Ann Acad Med Singapore 33 (4): 524-6. PMID 15329769. http://www.annals.edu.sg/pdf200408/V33N4p524.pdf.
  2. 2.0 2.1 Dascalescu, CM.; Wendum, D.; Gorin, NC. (Sep 2001). "Littoral-cell angioma as a cause of splenomegaly.". N Engl J Med 345 (10): 772-3. doi:10.1056/NEJM200109063451016. PMID 11547761. http://www.nejm.org/doi/full/10.1056/NEJM200109063451016.
  3. URL: http://www.merriam-webster.com/dictionary/littoral. Accessed on: 24 July 2011.
  4. URL: http://dictionary.reference.com/browse/littoral. Accessed on: 24 July 2011.