Difference between revisions of "Littoral cell angioma"

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#redirect [[Spleen#Littoral_cell_angioma]]
'''Littoral cell angioma''', abbreviated '''LCA''', is an uncommon benign [[vascular lesions|vascular lesion]] of the [[spleen]].
 
''Angioma'', in general, is dealt with in ''[[vascular malformations]]''.
==General==
Features:<ref name=pmid15329769>{{Cite journal  | last1 = Tan | first1 = YM. | last2 = Chuah | first2 = KL. | last3 = Wong | first3 = WK. | title = Littoral cell angioma of the spleen. | journal = Ann Acad Med Singapore | volume = 33 | issue = 4 | pages = 524-6 | month = Jul | year = 2004 | doi =  | PMID = 15329769 | url=http://www.annals.edu.sg/pdf200408/V33N4p524.pdf }}</ref>
*Rare.
*Benign.
 
Clinical:<ref name=pmid15329769/><ref name=pmid11547761>{{Cite journal  | last1 = Dascalescu | first1 = CM. | last2 = Wendum | first2 = D. | last3 = Gorin | first3 = NC. | title = Littoral-cell angioma as a cause of splenomegaly. | journal = N Engl J Med | volume = 345 | issue = 10 | pages = 772-3 | month = Sep | year = 2001 | doi = 10.1056/NEJM200109063451016 | PMID = 11547761 | url=http://www.nejm.org/doi/full/10.1056/NEJM200109063451016 }}</ref>
*Pyrexia (fever), splenomegaly, weight loss, solitary hypodense lesion on imaging.
 
Note:
*''Littoral cells'' = line vascular channels of the red pulp.<ref name=pmid15329769/>
**''Littoral'' = related to ''shore''.<ref>URL: [http://www.merriam-webster.com/dictionary/littoral http://www.merriam-webster.com/dictionary/littoral]. Accessed on: 24 July 2011.</ref><ref>URL: [http://dictionary.reference.com/browse/littoral http://dictionary.reference.com/browse/littoral]. Accessed on: 24 July 2011.</ref>
 
==Microscopic==
Features:<ref name=pmid15329769/>
*Anastoming, small vascular channels.
*Cystic spaces.
**May have papillary projections.<ref name=pmid11547761/>
 
DDx:<ref name=pmid15329769/>
*Vascular lesions:
**[[Hemangioendothelioma]].
**[[Angiosarcoma]].
**[[Hemangiopericytoma]].
**[[Splenic hamartoma]].
 
===Images===
www:
*[http://www.webpathology.com/image.asp?n=5&Case=382 LCA - low mag. (webpathology.com)].
*[http://www.webpathology.com/image.asp?n=6&Case=382 LCA - high mag. (webpathology.com)].
<gallery>
Image:Littoral_cell_angioma_of_the_spleen_-_very_low_mag.jpg | LCA - very low mag. (WC)
Image:Littoral_cell_angioma_of_the_spleen_-_intermed_mag.jpg | LCA - intermed. mag. (WC)
Image:Littoral_cell_angioma_of_the_spleen_-_very_high_mag.jpg | LCA - very high mag. (WC)
</gallery>
==IHC==
Features:<ref name=pmid15329769/>
*CD68 +ve.
*CD31 +ve
 
Others:
*CD34 -ve.
*Factor VIII +ve.
 
==See also==
*[[Spleen]].
 
==References==
{{Reflist|2}}


[[Category:Diagnosis]]
[[Category:Diagnosis]]
[[Category:Spleen]]

Revision as of 21:18, 16 February 2014

Littoral cell angioma, abbreviated LCA, is an uncommon benign vascular lesion of the spleen.

Angioma, in general, is dealt with in vascular malformations.

General

Features:[1]

  • Rare.
  • Benign.

Clinical:[1][2]

  • Pyrexia (fever), splenomegaly, weight loss, solitary hypodense lesion on imaging.

Note:

  • Littoral cells = line vascular channels of the red pulp.[1]
    • Littoral = related to shore.[3][4]

Microscopic

Features:[1]

  • Anastoming, small vascular channels.
  • Cystic spaces.
    • May have papillary projections.[2]

DDx:[1]

Images

www:

  • LCA - very low mag. (WC)

  • LCA - intermed. mag. (WC)

  • LCA - very high mag. (WC)

IHC

Features:[1]

  • CD68 +ve.
  • CD31 +ve

Others:

  • CD34 -ve.
  • Factor VIII +ve.

See also

References

  1. ↑ 1.0 1.1 1.2 1.3 1.4 1.5 Tan, YM.; Chuah, KL.; Wong, WK. (Jul 2004). "Littoral cell angioma of the spleen.". Ann Acad Med Singapore 33 (4): 524-6. PMID 15329769. http://www.annals.edu.sg/pdf200408/V33N4p524.pdf.
  2. ↑ 2.0 2.1 Dascalescu, CM.; Wendum, D.; Gorin, NC. (Sep 2001). "Littoral-cell angioma as a cause of splenomegaly.". N Engl J Med 345 (10): 772-3. doi:10.1056/NEJM200109063451016. PMID 11547761. http://www.nejm.org/doi/full/10.1056/NEJM200109063451016.
  3. ↑ URL: http://www.merriam-webster.com/dictionary/littoral. Accessed on: 24 July 2011.
  4. ↑ URL: http://dictionary.reference.com/browse/littoral. Accessed on: 24 July 2011.
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