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Difference between revisions of "Liposarcoma"
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*Most common malignant sarcoma in the retroperitoneum. | *Most common malignant sarcoma in the retroperitoneum. | ||
*Not all (large) retroperitoneal adipocytic tumours are liposarcomas. | *Not all (large) retroperitoneal adipocytic tumours are liposarcomas. | ||
*Prognosis - dependent on the location. | |||
**Retroperitoneal: poor. | |||
**Extremity: good - disease specific 5-year survival ~ 92%.<ref>{{Cite journal | last1 = Lietman | first1 = SA. | last2 = Barsoum | first2 = WK. | last3 = Goldblum | first3 = JR. | last4 = Marks | first4 = KE. | last5 = Mascha | first5 = E. | last6 = Sundaram | first6 = M. | last7 = Muschler | first7 = G. | title = A 20-year retrospective review of surgically treated liposarcoma at the Cleveland Clinic. | journal = Orthopedics | volume = 30 | issue = 3 | pages = 227-34 | month = Mar | year = 2007 | doi = | PMID = 17375550 }}</ref> | |||
Notes: | Notes: | ||
*Retroperitoneal sarcomas: #1: liposarcoma, #2: [[pleomorphic undifferentiated sarcoma]], #3: leiomyosarcoma, #4: [[MPNST]]. | *Retroperitoneal sarcomas: #1: liposarcoma, #2: [[pleomorphic undifferentiated sarcoma]], #3: [[leiomyosarcoma]], #4: [[MPNST]]. | ||
**Extremely rare in retroperitoneum: [[synovial sarcoma]]. | **Extremely rare in retroperitoneum: [[synovial sarcoma]]. | ||
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==IHC== | ==IHC== | ||
*MDM2 +ve.<ref name=pmid24227706>{{Cite journal | last1 = Mariño-Enríquez | first1 = A. | last2 = Hornick | first2 = JL. | last3 = Dal Cin | first3 = P. | last4 = Cibas | first4 = ES. | last5 = Qian | first5 = X. | title = Dedifferentiated liposarcoma and pleomorphic liposarcoma: a comparative study of cytomorphology and MDM2/CDK4 expression on fine-needle aspiration. | journal = Cancer Cytopathol | volume = 122 | issue = 2 | pages = 128-37 | month = Feb | year = 2014 | doi = 10.1002/cncy.21362 | PMID = 24227706 }}</ref> | *MDM2 +ve.<ref name=pmid24227706>{{Cite journal | last1 = Mariño-Enríquez | first1 = A. | last2 = Hornick | first2 = JL. | last3 = Dal Cin | first3 = P. | last4 = Cibas | first4 = ES. | last5 = Qian | first5 = X. | title = Dedifferentiated liposarcoma and pleomorphic liposarcoma: a comparative study of cytomorphology and MDM2/CDK4 expression on fine-needle aspiration. | journal = Cancer Cytopathol | volume = 122 | issue = 2 | pages = 128-37 | month = Feb | year = 2014 | doi = 10.1002/cncy.21362 | PMID = 24227706 }}</ref> | ||
*CDK4 +ve. | *CDK4 +ve.<ref name=pmid24227706/> | ||
*S-100 +ve ~1/3 of the time. | *S-100 +ve ~1/3 of the time. | ||
==See also== | ==See also== | ||