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Difference between revisions of "Lipofuscin"
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'''Lipofuscin''' is benign pigment that can be confused for melanin. | [[Image:Melanosis coli intermed mag.jpg|thumb|right|[[Micrograph]] showing lipofuscin in the colon; this is known as ''[[pseudomelanosis coli]]''. [[H&E stain]].]] | ||
[[Image:Stromal lipofuscinosis of the seminal vesicle - alt -- high mag.jpg |right|thumb|[[Micrograph]] showing stromal lipofuscinosis. [[H&E stain]].]]'''Lipofuscin''' is benign pigment that can be confused for melanin. It is also known as ''age pigment'', as it as associated strongly with aging.<ref name=pmid11976186>{{cite journal |authors=Porta EA |title=Pigments in aging: an overview |journal=Ann. N. Y. Acad. Sci. |volume=959 |issue= |pages=57–65 |date=April 2002 |pmid=11976186 |doi=10.1111/j.1749-6632.2002.tb02083.x |url=}}</ref> | |||
==Called "melanosis" when it is really lipofuscin== | ==Called "melanosis" when it is really lipofuscin== | ||
*Bladder lipofuscin pigmentation.<ref name=pmid31148387>{{cite journal | | *Bladder lipofuscin pigmentation.<ref name=pmid31148387>{{cite journal |authors=Atieh M, McIntire PJ, Kilic I, Picken MM, Flanigan RC, Barkan GA, Pambuccian SE |title=Lipofuscin pigmentation (so called "melanosis") of the bladder |journal=Diagn. Cytopathol. |volume=47 |issue=9 |pages=968–971 |date=September 2019 |pmid=31148387 |doi=10.1002/dc.24204 |url=}}</ref> | ||
*[[Pseudomelanosis coli]] also known as "melanosis coli".<ref name=pmid18666316>{{cite journal |author=Freeman HJ |title="Melanosis" in the small and large intestine |journal=World J. Gastroenterol. |volume=14 |issue=27 |pages=4296-9 |year=2008 |month=July |pmid=18666316 |doi= |url=http://www.wjgnet.com/1007-9327/14/4296.asp}}</ref> | *[[Pseudomelanosis coli]] also known as "melanosis coli".<ref name=pmid18666316>{{cite journal |author=Freeman HJ |title="Melanosis" in the small and large intestine |journal=World J. Gastroenterol. |volume=14 |issue=27 |pages=4296-9 |year=2008 |month=July |pmid=18666316 |doi= |url=http://www.wjgnet.com/1007-9327/14/4296.asp}}</ref> | ||
==Microscopic== | |||
Features: | |||
*Brown pigment. | |||
DDx: | |||
*Melanin. | |||
*Iron. | |||
*Bile. | |||
*Exogenous pigment. | |||
==Stains== | |||
Features: | |||
*[[PAS stain]] +ve.<ref name=pmid11976186>{{cite journal |authors=Porta EA |title=Pigments in aging: an overview |journal=Ann. N. Y. Acad. Sci. |volume=959 |issue= |pages=57–65 |date=April 2002 |pmid=11976186 |doi=10.1111/j.1749-6632.2002.tb02083.x |url=}}</ref> | |||
*[[Melanin stain]] -ve. | |||
==See also== | ==See also== | ||