Leukemia

The article addresses leukemia, which is uncommonly seen by anatomical pathologists. It is a subset of hematopathology. Lymphoma is discussed in the lymphoma article, and overlaps somewhat with this article as the clear distinction between the two is historical.

Definition

All of the following:

1. Morphologic abnormalities.
2. >20% blasts or recurrent cytogenetic abnormality.

Some recurrent cytogenetic abnormalities:

• t(8;21).
• inv(16).
• t(15;17).

Histomorphologic overview

Disease/Feature	Blast size	Auer rods	Granulation of cytoplasm
AML	larger	present	present
ALL	smaller	none	absent or present

See also

• Lymphoma.
• Myelodysplastic syndromes