Difference between revisions of "Leukemia"

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Retrieved from "https://librepathology.org/wiki/Leukemia"

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 | absent or present
 |}
+==Clinical factors==
+Clinical are important in the classification of leukemia.
+*Hx of [[myelodysplastic syndrome]]?
+*Chemotherapy?
+*[[Down syndrome]]?
+==Algorithms==
+There is a nice set of algorithms from D. Arber - that were presented at the 2009 USCAP.
+==Leukemia classification==
+AML:
+#AML.
+#AML with recurrent cytogenetic abnormalities.
+#AML from MDS.
+#AML in the setting of Down syndrome.
+ALL:
+#B cell.
+#B cell with recurrent cytogenetic abnormalities.
+#T cell.
+===AML with recurrent cytogenetic abnormalities===
+====t(8;21)====
+*t(8;21)(q22;q22).<ref>{{Cite journal  | last1 = Berger | first1 = R. | title = Translocation t(8;21)(q22;q22): cytogenetics and molecular biology. | journal = Nouv Rev Fr Hematol | volume = 36 Suppl 1 | issue =  | pages = S67-9 | month =  | year = 1994 | doi =  | PMID = 8177719 }}</ref>
+IHC:
+*CD34+, CD13+, MPO+ (cytoplasm), CD33+ (weak).
+*CD56+, CD117+.
+**Usu. assoc. with a bad prognosis.
+Flow cytometry:
+*CD19+, PAX5+, CD79a +/-.
+====inv(16)====
+*inv(16)(p13.1q22).<ref name=pmid16917916>{{Cite journal  | last1 = Lu | first1 = CM. | last2 = Murata-Collins | first2 = JL. | last3 = Wang | first3 = E. | last4 = Siddiqi | first4 = I. | last5 = Lawrence | first5 = HJ. | title = Concurrent acute myeloid leukemia with inv(16)(p13.1q22) and chronic lymphocytic leukemia: molecular evidence of two separate diseases. | journal = Am J Hematol | volume = 81 | issue = 12 | pages = 963-8 | month = Dec | year = 2006 | doi = 10.1002/ajh.20716 | PMID = 16917916 }}
+</ref>
+*Assoc. with myeloid sarcoma.
+Microscopic:
+*Blast count usu. ~20% (low).
+*Eosinophilic granules.
+**Used to be classified as "M4" with eosinophilia.
+IHC:
+*CD2+ -- common.
 ==See also==
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 ==References==
-{{Reflist|1}}
+{{Reflist|2}}
 [[Category:Haematopathology]]

Difference between revisions of "Leukemia"

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