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| ==Chronic myeloid leukemia== | | ==Chronic myeloid leukemia== |
| *Abbreviated ''CML''.
| | {{:Chronic myeloid leukemia}} |
| *[[AKA]] ''chronic myelogenous leukemia''.
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| ===General===
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| *Adults - usu. 50s or 60s.
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| Clinical - commonly:<ref>{{Ref PCPBoD8|336}}</ref>
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| *Leukocytosis - neutrophils, myelocytes, metamyelocytes, +/-eosinophilia, +/-basophilia.
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| Progression:
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| #Chronic phase - potentially curable.
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| #Accelerated phase.
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| #Blast crisis.
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| Treatment:
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| *[[Imatinib]].
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| Notes:
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| *Myeloblast (common granulocyte precursor) -> promyelocyte -> metamyelocyte -> myelocyte -> band -> mature myelocyte.<ref name=hemechart>URL: [http://commons.wikimedia.org/wiki/File:Hematopoiesis_%28human%29_diagram.png http://commons.wikimedia.org/wiki/File:Hematopoiesis_%28human%29_diagram.png]. Accessed on: 14 January 2012.</ref>
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| ===Microscopic===
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| Features:
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| *Bone marrow with too many granulocytes/granulocyte precursors.
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| **Granulocyte precursors:<ref name=hemechart>URL: [http://commons.wikimedia.org/wiki/File:Hematopoiesis_%28human%29_diagram.png http://commons.wikimedia.org/wiki/File:Hematopoiesis_%28human%29_diagram.png]. Accessed on: 14 January 2012.</ref>
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| **#Myeloblast (common granulocyte precursor) ~ 90% nucleus, multiple nucleoli.
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| **#*Should be less than 10%.
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| **#Promyelocyte (committed to a specific linage ([[neutrophil]], basophil or [[eosinophil]])) - dia. 2x mature, 40-50% nucleus, one [[nucleolus]].
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| **#Metamyelocyte - dia. 2x mature, 30-40% nucleus, no nucleolus.
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| **#Myelocyte - dia. 1x mature, 50-60% nucleus - kidney bean shape, no nucleolus.
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| **#Band - dia. 1x mature, 30-40% nucleus - C shape/irregular, no nucleolus.
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| ===IHC===
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| Features:<ref>{{Cite journal | last1 = Muñoz | first1 = L. | last2 = Bellido | first2 = M. | last3 = Sierra | first3 = J. | last4 = Nomdedéu | first4 = JF. | title = Flow cytometric detection of B cell abnormal maturation in chronic myeloid leukemia. | journal = Leukemia | volume = 14 | issue = 2 | pages = 339-40 | month = Feb | year = 2000 | doi = | PMID = 10673756 |URL = http://www.nature.com/leu/journal/v14/n2/full/2401549a.html }}</ref> (???)
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| *Chronic:
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| **CD20+ CD19+ CD10-.
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| *Accelerated:
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| **CD20+ CD19+ CD10+.
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| *Blast:
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| **CD20- CD19+ CD10+.
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| **CD34+ TdT+.<ref>URL: [http://path.upmc.edu/cases/case271.html http://path.upmc.edu/cases/case271.html]. Accessed on: 14 January 2012.</ref>
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| ===Molecular===
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| *t(9;22) BCR-ABL - '''required for diagnosis'''.
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| **May be found in other leukemias.
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| =See also= | | =See also= |