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Difference between revisions of "Leiomyoma"
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| Micro = spindle cells arranged in fascicles, +/-nuclear atypia, rare mitoses (allowable mitotic rate dependent on specific site) | | Micro = spindle cells arranged in fascicles, +/-nuclear atypia, rare mitoses (allowable mitotic rate dependent on specific site) | ||
| Subtypes = lipoleiomyoma, hypercellular leiomyoma, atypical leiomyoma (symplastic leiomyoma), benign metastasizing leiomyoma | | Subtypes = lipoleiomyoma, hypercellular leiomyoma, atypical leiomyoma (symplastic leiomyoma), benign metastasizing leiomyoma | ||
| LMDDx = [[leiomyosarcoma]], [[STUMP]], [[dermatomyofibroma]] | | LMDDx = [[leiomyosarcoma]], [[STUMP]], [[dermatomyofibroma]], [[adenomatoid tumour]] | ||
| Stains = | | Stains = | ||
| IHC = | | IHC = | ||
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*Large & multiple leiomyomas are associated with infertility. | *Large & multiple leiomyomas are associated with infertility. | ||
*May be part of ''[[hereditary leiomyomatosis and renal cell cancer]]'' (HLRCC). | *May be part of ''[[hereditary leiomyomatosis and renal cell cancer]]'' (HLRCC). | ||
**In one series, 68% with HLRCC were diagnosed at age <=30 years.<ref name=pmid16597677>{{Cite journal | last1 = Pithukpakorn | first1 = M. | last2 = Wei | first2 = MH. | last3 = Toure | first3 = O. | last4 = Steinbach | first4 = PJ. | last5 = Glenn | first5 = GM. | last6 = Zbar | first6 = B. | last7 = Linehan | first7 = WM. | last8 = Toro | first8 = JR. | title = Fumarate hydratase enzyme activity in lymphoblastoid cells and fibroblasts of individuals in families with hereditary leiomyomatosis and renal cell cancer. | journal = J Med Genet | volume = 43 | issue = 9 | pages = 755-62 | month = Sep | year = 2006 | doi = 10.1136/jmg.2006.041087 | PMID = 16597677 }} | |||
</ref> | |||
===Colonic leiomyoma=== | ===Colonic leiomyoma=== | ||
{{Main|Colonic leiomyoma}} | {{Main|Colonic leiomyoma}} | ||
===Renal leiomyoma=== | |||
{{Main|Renal leiomyoma}} | |||
==Gross== | ==Gross== | ||
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*Dermatomyofibroma.<ref name=Ref_Derm533>{{Ref Derm|533}}</ref> | *Dermatomyofibroma.<ref name=Ref_Derm533>{{Ref Derm|533}}</ref> | ||
*[[Myopericytoma]] / [[myofibroma]]. | *[[Myopericytoma]] / [[myofibroma]]. | ||
*[[Adenomatoid tumour]] - esp. for lipoleiomyoma. | |||
*[[Smooth muscle tumour of uncertain malignant potential]] (STUMP) - do not fulfill criteria for leiomyosarcoma. | *[[Smooth muscle tumour of uncertain malignant potential]] (STUMP) - do not fulfill criteria for leiomyosarcoma. | ||
*[[Epstein-Barr virus-associated smooth muscle tumour]] - very rare. | |||
===Variants=== | ===Variants=== | ||