Difference between revisions of "Large epithelioid tumours"

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Large epithelioid tumours (view source)

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'''Large epithelioid tumours''' are common and represent a large [[differential diagnosis]] when viewed generally.
[[Image:Epithelioid angiosarcoma - very high mag.jpg|thumb|200px|right|A large epithelioid tumour ([[epithelioid angiosarcoma]]). [[H&E stain]].]]
'''Large epithelioid tumours''' are common and represent a large [[differential diagnosis]] when viewed generally.
 
[[Malignant]] epithelioid lesions are often [[carcinoma]]s... but may be a large number different tumours.
 
A more general discussion of epithelioid lesions is in the ''[[epithelioid cell lesions]]'' article.  Small epithelioid lesions are dealt with in the ''[[small round cell tumours]]'' article.


==General differential diagnosis==
==General differential diagnosis==
Adapted from ''Miller'' with modifications:<ref name=miller>Miller RT. (Sep 2013). ''Atlantic Diagnostic Immunohistochemistry Symposium''. St. John's, NL, Canada.</ref>
{| class="wikitable sortable"  
{| class="wikitable sortable"  
! Tumour
! Tumour
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| [[Myoepithelioma of soft tissue]]  
| [[Myoepithelioma of soft tissue]]  
| Epithelial tumours  
| Epithelial tumours  
| may mimic [[extraskeletal myxoid chondrosarcoma]] or proximal variant of [[epithelial sarcoma]]  
| may mimic [[extraskeletal myxoid chondrosarcoma]] or proximal variant of [[epithelioid sarcoma]]  
|-
|-
| [[Acinar cell carcinoma]]  
| [[Acinar cell carcinoma]]  
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| <ref name=pmid11224605>{{Cite journal | last1 = Kutzner| first1 = H.| last2 = Mentzel| first2 = T.| last3 = Kaddu| first3 = S.| last4 = Soares| first4 = LM.| last5 = Sangueza| first5 = OP.| last6 = Requena| first6 = L.| title = Cutaneous myoepithelioma: an under-recognized cutaneous neoplasm composed of myoepithelial cells.| journal = Am J Surg Pathol| volume = 25| issue = 3| pages = 348-55| month = Mar| year = 2001| doi = | PMID = 11224605 }}</ref>  
| <ref name=pmid11224605>{{Cite journal | last1 = Kutzner| first1 = H.| last2 = Mentzel| first2 = T.| last3 = Kaddu| first3 = S.| last4 = Soares| first4 = LM.| last5 = Sangueza| first5 = OP.| last6 = Requena| first6 = L.| title = Cutaneous myoepithelioma: an under-recognized cutaneous neoplasm composed of myoepithelial cells.| journal = Am J Surg Pathol| volume = 25| issue = 3| pages = 348-55| month = Mar| year = 2001| doi = | PMID = 11224605 }}</ref>  
|-
|-
| [[Cutaneous adnexal tumours (spiradenoma, acrospiroma)]]  
| Cutaneous adnexal tumours ([[spiradenoma]], [[acrospiroma]])
| Epithelial tumours  
| Epithelial tumours  
|   
|   
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| consider hepatoid variant  
| consider hepatoid variant  
|-
|-
| [[Choricarcinoma]]  
| [[Choriocarcinoma]]  
| Germ- cell / Sex-Cord Stromal  
| Germ- cell / Sex-Cord Stromal  
|   
|   
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|   
|   
|-
|-
| [[High grade endometrial stromal sarcoma]]  
| [[Endometrial stromal sarcoma]]
| Germ- cell / Sex-Cord Stromal
| high grade
|-
| [[Lipid cell tumour of ovary]]  
| Germ- cell / Sex-Cord Stromal  
| Germ- cell / Sex-Cord Stromal  
|   
|   
|-
|-
| [[Lipid Cell tumour of ovary]]  
| [[Sertoli cell tumour]]  
| Germ- cell / Sex-Cord Stromal  
| Germ- cell / Sex-Cord Stromal  
|   
| also [[Sertoli-Leydig cell tumour]]  
|-
|-
| [[Sertoli or Leydig cell]]  
| [[Leydig cell tumour]]  
| Germ- cell / Sex-Cord Stromal  
| Germ- cell / Sex-Cord Stromal  
|
| also [[Sertoli-Leydig cell tumour]]
|-
|-
| [[Epithelioid trophoblastic tumour]]  
| [[Epithelioid trophoblastic tumour]]  
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| <ref name=pmid10571512>{{Cite journal | last1 = Hamazaki| first1 = S.| last2 = Nakamoto| first2 = S.| last3 = Okino| first3 = T.| last4 = Tsukayama| first4 = C.| last5 = Mori| first5 = M.| last6 = Taguchi| first6 = K.| last7 = Okada| first7 = S.| title = Epithelioid trophoblastic tumor: morphological and immunohistochemical study of three lung lesions.| journal = Hum Pathol| volume = 30| issue = 11| pages = 1321-7| month = Nov| year = 1999| doi = | PMID = 10571512 }}</ref><ref name=pmid9808132>{{Cite journal | last1 = Shih| first1 = IM.| last2 = Kurman| first2 = RJ.| title = Epithelioid trophoblastic tumor: a neoplasm distinct from choriocarcinoma and placental site trophoblastic tumor simulating carcinoma.| journal = Am J Surg Pathol| volume = 22| issue = 11| pages = 1393-403| month = Nov| year = 1998| doi = | PMID = 9808132 }}</ref>  
| <ref name=pmid10571512>{{Cite journal | last1 = Hamazaki| first1 = S.| last2 = Nakamoto| first2 = S.| last3 = Okino| first3 = T.| last4 = Tsukayama| first4 = C.| last5 = Mori| first5 = M.| last6 = Taguchi| first6 = K.| last7 = Okada| first7 = S.| title = Epithelioid trophoblastic tumor: morphological and immunohistochemical study of three lung lesions.| journal = Hum Pathol| volume = 30| issue = 11| pages = 1321-7| month = Nov| year = 1999| doi = | PMID = 10571512 }}</ref><ref name=pmid9808132>{{Cite journal | last1 = Shih| first1 = IM.| last2 = Kurman| first2 = RJ.| title = Epithelioid trophoblastic tumor: a neoplasm distinct from choriocarcinoma and placental site trophoblastic tumor simulating carcinoma.| journal = Am J Surg Pathol| volume = 22| issue = 11| pages = 1393-403| month = Nov| year = 1998| doi = | PMID = 9808132 }}</ref>  
|-
|-
| [[placental site trophoblastic tumour]]  
| [[Placental site trophoblastic tumour]]  
| Germ- cell / Sex-Cord Stromal  
| Germ- cell / Sex-Cord Stromal  
|(USCAP04, Gyn spec conf, case 3, vaginal  
|(USCAP04, Gyn spec conf, case 3, vaginal  
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| "True" histiocytic lymphoma  
| "True" histiocytic lymphoma  
|-
|-
| [[Langerhan's cell histiocytosis ]]  
| [[Langerhans cell histiocytosis ]]  
| Hematolymphoid / Histiocytic tumours  
| Hematolymphoid / Histiocytic tumours  
|   
|   
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|   
|   
|-
|-
| [[Extramedullary megakaryoblastic leuk.]]  
| [[Extramedullary megakaryoblastic leukemia]]  
| Hematolymphoid / Histiocytic tumours  
| Hematolymphoid / Histiocytic tumours  
|   
|   
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| also [[pheochromocytoma]]  
| also [[pheochromocytoma]]  
|-
|-
| [[High grade olfactory neuroblastoma]]  
| High grade [[olfactory neuroblastoma]]  
| Neural - Neuroendocrine - Neuraxis Tumours  
| Neural - Neuroendocrine - Neuraxis Tumours  
|   
|   
|-
|-
| [[Epithelioid MPNST]]  
| Epithelioid [[MPNST]]  
| Neural - Neuroendocrine - Neuraxis Tumours  
| Neural - Neuroendocrine - Neuraxis Tumours  
| reported to have focal melanocytic differentiation in some cases{{fact}}  
| reported to have focal melanocytic differentiation in some cases{{fact}}  
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|   
|   
|-
|-
| [[Pleomorphic rhabdomyosarcoma]]  
| [[Rhabdomyosarcoma]], not otherwise specified ([[pleomorphic rhabdomyosarcoma]])
| Muscle-related tumours  
| Muscle-related tumours  
|   
|   
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|   
|   
|-
|-
| [[Epithelioid glomus tumor]]  
| [[Epithelioid glomus tumour]]  
| Muscle-related tumours  
| Muscle-related tumours  
|   
|   
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|   
|   
|-
|-
| [[Epith sarcoma-like hemangioendothelioma ]]  
| [[Epithelioid sarcoma-like hemangioendothelioma]]  
| Vascular tumours  
| Vascular tumours  
|   
| <ref name=pmid12502927>{{Cite journal | last1 = Billings | first1 = SD. | last2 = Folpe | first2 = AL. | last3 = Weiss | first3 = SW. | title = Epithelioid sarcoma-like hemangioendothelioma. | journal = Am J Surg Pathol | volume = 27 | issue = 1 | pages = 48-57 | month = Jan | year = 2003 | doi =  | PMID = 12502927 }}</ref>
|-
|-
| [[Composite hemangioendothelioma]]  
| [[Composite hemangioendothelioma]]  
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|S-100 +ve  
|S-100 +ve  
|-
|-
| [[Diffuse type tenosynovial giant cell tumor]]  
| [[Diffuse type tenosynovial giant cell tumour]]  
| Hematolymphoid / Histiocytic tumours  
| Hematolymphoid / Histiocytic tumours  
|   
|   
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|   
|   
|-
|-
| [[Inflammatory myxohyaline tumor of distal extremities with virocyte or Reed-Sternberg like cells]]  
| [[Inflammatory myxohyaline tumour of distal extremities with virocyte or Reed-Sternberg like cells]]  
| Myofibroblastic - fibroblastic tumours  
| Myofibroblastic - fibroblastic tumours  
|   
|   
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|   
|   
|-
|-
| [[Epithelioid osteosarcoma]]  
| Epithelioid [[osteosarcoma]]  
| Chondro-osseous tumours  
| Chondro-osseous tumours  
|   
| <ref>{{Cite journal | last1 = Amanatullah | first1 = DF. | last2 = Ngann | first2 = KK. | last3 = Borys | first3 = D. | last4 = Tamurian | first4 = RM. | title = Progression of aggressive metastatic carcinosarcoma after treatment of epithelioid osteosarcoma. | journal = Orthopedics | volume = 33 | issue = 6 | pages = 445 | month = Jun | year = 2010 | doi = 10.3928/01477447-20100429-26 | PMID = 20806764 }}</ref>
|-
|-
| [[Extraskeletal myxoid chondrosarcoma, high grade]]
| [[Extraskeletal myxoid chondrosarcoma]], high grade  
| Chondro-osseous tumours  
| Chondro-osseous tumours  
|   
|   
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*[[Basics]].
*[[Basics]].
*[[Pleomorphic tumours]].
*[[Pleomorphic tumours]].
*[[Small round cell tumours]].


==References==
==References==
Michael
48,474

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