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Difference between revisions of "Kimura disease"
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'''Kimura disease''' is a rare disease with abundant eosinophils. It may show-up in a [[lymph node]] specimen. | {{ Infobox diagnosis | ||
| Name = {{PAGENAME}} | |||
| Image = Kimura_disease_-_very_high_mag.jpg | |||
| Width = | |||
| Caption = Kimura disease. [[H&E stain]]. | |||
| Micro = eosinophils and thick walled [[blood vessel]]s with [[hobnail]]ed endothelial cells | |||
| Subtypes = | |||
| LMDDx = [[angiolymphoid hyperplasia with eosinophilia]], [[drug reaction]], infection (parasitic), [[lymphoma]], [[LCH]] | |||
| Stains = | |||
| IHC = | |||
| EM = | |||
| Molecular = | |||
| IF = | |||
| Gross = | |||
| Grossing = | |||
| Site = [[lymph node]], head and neck | |||
| Assdx = | |||
| Syndromes = | |||
| Clinicalhx = | |||
| Signs = | |||
| Symptoms = | |||
| Prevalence = extremely rare | |||
| Bloodwork = eosinophilia | |||
| Rads = | |||
| Endoscopy = | |||
| Prognosis = | |||
| Other = | |||
| ClinDDx = | |||
}} | |||
'''Kimura disease''' is a rare disease with abundant eosinophils. It may show-up in a [[lymph node]] specimen. It is similar to ''[[angiolymphoid hyperplasia with eosinophilia]]''.<ref>URL: [http://emedicine.medscape.com/article/1082603-overview http://emedicine.medscape.com/article/1082603-overview]. Accessed on: 14 January 2012.</ref> | |||
==General== | ==General== | ||
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Features:<ref name=Ref_ILNP190>{{Ref ILNP|190}}</ref> | Features:<ref name=Ref_ILNP190>{{Ref ILNP|190}}</ref> | ||
*Angiolymphoid proliferation. | *Angiolymphoid proliferation. | ||
**Thick walled blood vessels with (plump) hobnail endothelial cells.<ref>URL: [http://emedicine.medscape.com/article/1098777-diagnosis http://emedicine.medscape.com/article/1098777-diagnosis]. Accessed on: 8 August 2010.</ref> | **Thick walled blood vessels with (plump) [[hobnail]] endothelial cells.<ref>URL: [http://emedicine.medscape.com/article/1098777-diagnosis http://emedicine.medscape.com/article/1098777-diagnosis]. Accessed on: 8 August 2010.</ref> | ||
*Eosinophils - abundant - '''key feature'''. | *Eosinophils - abundant - '''key feature'''. | ||
DDx: | |||
*Drug reaction. | |||
*Parasitic infection. | |||
*[[Angiolymphoid hyperplasia with eosinophilia]]. | |||
Notes: | Notes: | ||
*Abundant eosinophils: consider Langerhans cell histiocytosis. | *In a lymph node... it may be signed-out as ''reactive lymphadenitis with follicular hyperplasia and prominent eosinophils, see comment.'' | ||
*Abundant eosinophils: consider [[Langerhans cell histiocytosis]]. | |||
Images | ===Images=== | ||
<gallery> | |||
Image:Kimura_disease_-_very_high_mag.jpg | Kimura disease - very high mag. (WC) | |||
Image:Kimura_disease_-_high_mag.jpg | Kimura disease - high mag. (WC) | |||
Image:Kimura_disease_-_intermed_mag.jpg | Kimura disease - intermed. mag. (WC) | |||
</gallery> | |||
==IHC== | ==IHC== | ||
*Used to rule-out a clonal population. | *Used to rule-out a clonal population, i.e. [[lymphoma]]. | ||
==See also== | ==See also== | ||
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[[Category:Weird stuff]] | [[Category:Weird stuff]] | ||
[[Category:Diagnosis]] | |||