Difference between revisions of "Kimura disease"

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'''Kimura disease''' is a rare disease with abundant eosinophils.  It may show-up in a [[lymph node]] specimen.
'''Kimura disease''' is a rare disease with abundant eosinophils.  It may show-up in a [[lymph node]] specimen. It is similar to ''angiolymphoid hyperplasia with eosinophilia''.<ref>URL: [http://emedicine.medscape.com/article/1082603-overview http://emedicine.medscape.com/article/1082603-overview]. Accessed on: 14 January 2012.</ref>


==General==
==General==

Revision as of 03:55, 15 January 2012

Kimura disease is a rare disease with abundant eosinophils. It may show-up in a lymph node specimen. It is similar to angiolymphoid hyperplasia with eosinophilia.[1]

General

  • AKA eosinophilic lymphogranuloma, Kimura disease.
  • Chronic inflammatory disorder - suspected to be infectious.

Clinical:

  • Usually neck, periauricular.
  • Peripheral blood eosinophilia.
  • Increased blood IgE.

Epidemiology

  • Males > females.
  • Young.
  • Asian.

Microscopic

Features:[2]

  • Angiolymphoid proliferation.
    • Thick walled blood vessels with (plump) hobnail endothelial cells.[3]
  • Eosinophils - abundant - key feature.

DDx:

  • Drug reaction.
  • Parasitic infection.

Notes:

  • In a lymph node... it may be signed-out as reactive lymphadenitis with follicular hyperplasia and prominent eosinophils, see comment.
  • Abundant eosinophils: consider Langerhans cell histiocytosis.

Images:

IHC

  • Used to rule-out a clonal population, i.e. lymphoma.

See also

References

  1. URL: http://emedicine.medscape.com/article/1082603-overview. Accessed on: 14 January 2012.
  2. Ioachim, Harry L; Medeiros, L. Jeffrey (2008). Ioachim's Lymph Node Pathology (4th ed.). Lippincott Williams & Wilkins. pp. 190. ISBN 978-0781775960.
  3. URL: http://emedicine.medscape.com/article/1098777-diagnosis. Accessed on: 8 August 2010.