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Difference between revisions of "Kikuchi disease"
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'''Kikuchi disease''', is a rare [[lymph node pathology]]. | {{ Infobox diagnosis | ||
| Name = {{PAGENAME}} | |||
| Image = Histiocytic_necrotizing_lymphadenitis_-_very_high_mag.jpg | |||
| Width = | |||
| Caption = Kikuchi disease. [[H&E stain]]. | |||
| Micro = histiocytes, necrosis (paracortical areas) without neutrophils, bland lymphocytes, plasmacytoid dendritic cells | |||
| Subtypes = | |||
| LMDDx = [[systemic lupus erythematosus lymphadenopathy]] | |||
| Stains = | |||
| IHC = done to exclude lymphoma | |||
| EM = | |||
| Molecular = | |||
| IF = | |||
| Gross = | |||
| Grossing = | |||
| Site = [[lymph node]] - see ''[[lymph node pathology]]'' | |||
| Assdx = | |||
| Syndromes = | |||
| Clinicalhx = | |||
| Signs = +/-fever | |||
| Symptoms = | |||
| Prevalence = | |||
| Bloodwork = | |||
| Rads = | |||
| Endoscopy = | |||
| Prognosis = usu. good - self-limited | |||
| Other = | |||
| ClinDDx = [[lymphoma]], other causes of lymphadenopathy | |||
}} | |||
'''Kikuchi disease''', is a rare [[lymph node pathology|pathology of the lymph nodes]]. | |||
It is also known as '''histiocytic necrotising lymphadenitis''',<ref name="pmid15570824">{{cite journal |author=Kaushik V, Malik TH, Bishop PW, Jones PH |title=Histiocytic necrotising lymphadenitis (Kikuchi's disease): a rare cause of cervical lymphadenopathy |journal=Surgeon |volume=2 |issue=3 |pages=179–82 |year=2004 |month=June |pmid=15570824 |doi= |url=}}</ref> abbreviated '''HNL''', and '''Kikuchi-Fujimoto disease'''. | It is also known as '''histiocytic necrotising lymphadenitis''',<ref name="pmid15570824">{{cite journal |author=Kaushik V, Malik TH, Bishop PW, Jones PH |title=Histiocytic necrotising lymphadenitis (Kikuchi's disease): a rare cause of cervical lymphadenopathy |journal=Surgeon |volume=2 |issue=3 |pages=179–82 |year=2004 |month=June |pmid=15570824 |doi= |url=}}</ref> abbreviated '''HNL''', and '''Kikuchi-Fujimoto disease'''. | ||
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*Rare disease that may mimic [[cancer]], esp. [[lymphoma]]. | *Rare disease that may mimic [[cancer]], esp. [[lymphoma]]. | ||
**May cause fever & systemic symptoms.<ref name=pmid20121621>{{cite journal |author=Hutchinson CB, Wang E |title=Kikuchi-Fujimoto disease |journal=Arch. Pathol. Lab. Med. |volume=134 |issue=2 |pages=289–93 |year=2010 |month=February |pmid=20121621 |doi= |url=}}</ref> | **May cause fever & systemic symptoms.<ref name=pmid20121621>{{cite journal |author=Hutchinson CB, Wang E |title=Kikuchi-Fujimoto disease |journal=Arch. Pathol. Lab. Med. |volume=134 |issue=2 |pages=289–93 |year=2010 |month=February |pmid=20121621 |doi= |url=}}</ref> | ||
*Associated with the subsequent diagnosis of [[systemic lupus erythematosus]].<ref name=pmid24157995>{{Cite journal | last1 = Scully | first1 = DF. | last2 = Walsh | first2 = C. | last3 = Eskander | first3 = HF. | last4 = Kane | first4 = D. | title = Kikuchi-Fujimoto disease--an unusual mimicker? | journal = N Z Med J | volume = 126 | issue = 1383 | pages = 85-8 | month = Sep | year = 2013 | doi = | PMID = 24157995 }}</ref> | |||
Epidemiology:<ref name=pmid20121621/> | Epidemiology:<ref name=pmid20121621/> | ||
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DDx: | DDx: | ||
*Non-Hodgkin lymphoma. | *[[Non-Hodgkin lymphoma]]. | ||
*[[Systemic lupus erythematosus]]. | *[[Systemic lupus erythematosus]]. | ||
**Have ''hematoxyphil bodies'' in necrotic foci. | **Have ''hematoxyphil bodies'' in necrotic foci. | ||