Keratocystic odontogenic tumour

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Keratocystic odontogenic tumour, abbreviated KOT, is an uncommon odontogenic tumour.

Keratocystic odontogenic tumour
Diagnosis in short

Keratocystic odontogenic tumour. H&E stain.

LM Stratified epithelium with "ribbon-like appearance" with palisaded basal cell layer, parakeratosis, artefactual separation of epithelium from the basement membrane
LM DDx odontogenic cyst (dentigerous cyst), squamous cell carcinoma
Site usually mandible

Syndromes nevoid basal cell carcinoma syndrome

Signs mass lesion
Prevalence uncommon
Clin. DDx ameloblastoma
Keratocystic odontogenic tumour
External resources
EHVSC 10179

It was previously known as odontogenic keratocyst, abbreviated OKC.[1]

General

Clinical

Features:[2]

  • Most common presentation: swelling.

Gross

  • Location: usually mandible.
  • May mimic ameloblastoma radiologically.

Microscopic

Features: [3]

  • Stratified epithelium (resembling squamous epithelium) with:
    • "Ribbon-like appearance" - important.
      • Typically 8-10 cell layers thick - with relatively uniform thickness.
      • Lacks rete ridges.
    • Palisaded basal cell layer.
  • Parakeratosis (keratinized cells with nuclei) - key feature.
  • Artefactual separation of epithelium from the basement membrane.

DDx:

Images

www:

See also

References

  1. Madras, J.; Lapointe, H. (Mar 2008). "Keratocystic odontogenic tumour: reclassification of the odontogenic keratocyst from cyst to tumour.". J Can Dent Assoc 74 (2): 165-165h. PMID 18353202.
  2. Habibi, A.; Saghravanian, N.; Habibi, M.; Mellati, E.; Habibi, M. (Sep 2007). "Keratocystic odontogenic tumor: a 10-year retrospective study of 83 cases in an Iranian population.". J Oral Sci 49 (3): 229-35. PMID 17928730.
  3. Thompson LDR. Head and neck pathology - (Foundations in diagnostic pathology). Goldblum JR, Ed.. Churchill Livingstone. 2006. ISBN 0-443-06960-3.
  4. Macdonald-Jankowski, DS. (Dec 2010). "Orthokeratinized odontogenic cyst: a systematic review.". Dentomaxillofac Radiol 39 (8): 455-67. doi:10.1259/dmfr/19728573.
  5. URL: http://www.sciencedirect.com/science/article/pii/S0968605305000992#fig5. Accessed on: 11 March 2013.