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Difference between revisions of "Keratoacanthoma"
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| Width = | | Width = | ||
| Caption = Keratoacanthoma. [[H&E stain]]. | | Caption = Keratoacanthoma. [[H&E stain]]. | ||
| Micro = | | Micro = keratin plug, downward cupping of the epidermis, minimal keratinocyte atypia, +/- keratinocytes with glassy pink cytoplasm | ||
| Subtypes = | | Subtypes = | ||
| LMDDx = | | LMDDx = [[squamous cell carcinoma of the skin|squamous cell carcinoma]], [[verruca vulgaris]], [[pseudoepitheliomatous hyperplasia]] | ||
| Stains = | | Stains = | ||
| IHC = | | IHC = | ||
| Line 17: | Line 17: | ||
| Assdx = | | Assdx = | ||
| Syndromes = | | Syndromes = | ||
| Signs = | | Clinicalhx = | ||
| Signs = rapid growth | |||
| Symptoms = | | Symptoms = | ||
| Prevalence = | | Prevalence = uncommon | ||
| Bloodwork = | | Bloodwork = | ||
| Rads = | | Rads = | ||
| Endoscopy = | | Endoscopy = | ||
| Prognosis = | | Prognosis = good | ||
| Other = | | Other = | ||
| ClinDDx = | | ClinDDx = [[squamous cell carcinoma of the skin|squamous cell carcinoma]] | ||
}} | }} | ||
'''Keratoacanthoma''' is clinically worrisome lesion that classically arise on the nose. | '''Keratoacanthoma''' is clinically worrisome lesion that classically arise on the nose. | ||
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</pre> | </pre> | ||
===Micro=== | ====Micro==== | ||
The sections show hair-bearing skin with a dome-shaped lesion that consists of a cup-shaped epidermal rim, and a large plug of keratin. The lesion is surrounded by a mild patchy lymphoplasmacytic infiltrate. No mitotic activity is apparent. The keratinocytes have minimal atypia and mature to the surface. A granular layer is present. The lesion is completely excised in the plane of section. | The sections show hair-bearing skin with a dome-shaped lesion that consists of a cup-shaped epidermal rim, and a large plug of keratin. The lesion is surrounded by a mild patchy lymphoplasmacytic infiltrate. No mitotic activity is apparent. The keratinocytes have minimal atypia and mature to the surface. A granular layer is present. The lesion is completely excised in the plane of section. | ||
There is no | There is no hypergranulosis. No koilocytes are seen. Solar elastosis is present. | ||
===Non-believers in the diagnosis=== | |||
<pre> | |||
Skin Lesion, Left Leg, Excision: | |||
- WELL-DIFFERENTIATED SQUAMOUS CELL CARCINOMA, KERATOACANTHOMA-LIKE, | |||
margins clear. | |||
</pre> | |||
====Micro==== | |||
The sections show hair-bearing skin with a dome-shaped lesion that consists of a cup-shaped epidermal rim, and a large plug of keratin. The lesion has a pushing border and is surrounded by a mild patchy lymphoplasmacytic infiltrate. Mitotic activity is not readily apparent. The keratinocytes have minimal atypia. The lesion is completely excised in the plane of section. No koilocytes are seen. Solar elastosis is present. | |||
==See also== | ==See also== | ||