Keloid

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Keloid
Diagnosis in short

Keloid. H&E stain.

LM thick collagen bundles - surrounded by paler staining fibroblasts, loss of adnexal structures
LM DDx hypertrophic scar
Site skin

Clinical history typically dark skinned individuals
Prognosis benign
Hypertrophic scar redirects here.

Keloid is an uncommon abnormal scarring.

General

  • Sites of previous trauma/surgery, esp. in dark skinned individuals.[1]

Note:

  • Reported as "keloidal-type collagen"; the clinician decides between hypertrophic scar and keloid.

Microscopic

Features:[1]

  • Thick collagen bundles - surrounded by paler staining fibroblasts - key feature.
  • Lesion replaces adnexal structures, e.g. hair, sweat glands.

DDx:

  • Hypertrophic scar.[2]

Images

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SKIN LESION, LEFT SCAPULA, EXCISION:
- DERMAL SCAR WITH KELOIDAL-TYPE COLLAGEN, SEE COMMENT.

COMMENT:
The findings are consistent with a hypertrophic scar or keloid; clinical correlation is required.

Clinical provided

SKIN LESION, LEFT NIPPLE AREOLA, EXCISION:
- DERMAL SCAR WITH KELOIDAL-TYPE COLLAGEN, CONSISTENT WITH HYPERTROPHIC SCAR.

See also

References

  1. 1.0 1.1 Humphrey, Peter A; Dehner, Louis P; Pfeifer, John D (2008). The Washington Manual of Surgical Pathology (1st ed.). Lippincott Williams & Wilkins. pp. 492. ISBN 978-0781765275.
  2. Gauglitz, GG.; Korting, HC.; Pavicic, T.; Ruzicka, T.; Jeschke, MG.. "Hypertrophic scarring and keloids: pathomechanisms and current and emerging treatment strategies.". Mol Med 17 (1-2): 113-25. doi:10.2119/molmed.2009.00153. PMC 3022978. PMID 20927486. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3022978/.