Juxtaglomerular cell tumour
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Juxtaglomerular cell tumour, abbreviated JCT, is a rare kidney tumour.
It is also known as juxtaglomerular tumour and reninoma.[1]
General
- Rare.
- Etiology: increased renin.
Clinical:[1]
- Hypertension.
- Increased aldosterone.
- Causes hypokalemia.
- Increased plasma renin.
Microscopic
Features:[2]
- Polygonal cells.
- Abundant granular, eosinophilic cytoplasm.[3]
- Perinuclear halo.
DDx:
- Chromophobe renal cell carcinoma, eosinophilic variant.
Image:
Stains
Cytoplasmic granules.[3]
- PAS +ve.
- PASD +ve.
IHC
Features:[2]
- Actin +ve.
- Cytokeratin -ve.
- HMB-45 -ve.
EM
Features:
- Vesicles - contain renin.[4]
See also
References
- ↑ 1.0 1.1 Wong, L.; Hsu, TH.; Perlroth, MG.; Hofmann, LV.; Haynes, CM.; Katznelson, L. (Feb 2008). "Reninoma: case report and literature review.". J Hypertens 26 (2): 368-73. doi:10.1097/HJH.0b013e3282f283f3. PMID 18192852.
- ↑ 2.0 2.1 2.2 Chao, CT.; Chang, FC.; Wu, VC.; Chen, JC. (Jan 2011). "Reninoma.". Kidney Int 79 (2): 260. doi:10.1038/ki.2010.445. PMID 21191395.
- ↑ 3.0 3.1 Hanna, W.; Tepperman, B.; Logan, AG.; Robinette, MA.; Colapinto, R.; Phillips, MJ. (Apr 1979). "Juxtaglomerular cell tumour (reninoma) with paroxysmal hypertension.". Can Med Assoc J 120 (8): 957-9. PMID PMC = 1819229 436071 PMC = 1819229.
- ↑ URL: http://path.upmc.edu/cases/case29/micro.html. Accessed on: 18 December 2011.