Difference between revisions of "Juxtaglomerular cell tumour"

From Libre Pathology
Jump to navigation Jump to search
Line 1: Line 1:
'''Juxtaglomerular cell tumour''', abbreviated '''JCT''', is a rare [[kidney tumour]].
'''Juxtaglomerular cell tumour''', abbreviated '''JCT''', is a rare [[kidney tumour]] associated with [[hypertension]] and typically seen in adolescents or young adults.


It is also known as '''juxtaglomerular tumour''' and '''reninoma'''.<ref name=pmid18192852>{{Cite journal  | last1 = Wong | first1 = L. | last2 = Hsu | first2 = TH. | last3 = Perlroth | first3 = MG. | last4 = Hofmann | first4 = LV. | last5 = Haynes | first5 = CM. | last6 = Katznelson | first6 = L. | title = Reninoma: case report and literature review. | journal = J Hypertens | volume = 26 | issue = 2 | pages = 368-73 | month = Feb | year = 2008 | doi = 10.1097/HJH.0b013e3282f283f3 | PMID = 18192852 }}</ref>
It is also known as '''juxtaglomerular tumour''' and '''reninoma'''.<ref name=pmid18192852>{{Cite journal  | last1 = Wong | first1 = L. | last2 = Hsu | first2 = TH. | last3 = Perlroth | first3 = MG. | last4 = Hofmann | first4 = LV. | last5 = Haynes | first5 = CM. | last6 = Katznelson | first6 = L. | title = Reninoma: case report and literature review. | journal = J Hypertens | volume = 26 | issue = 2 | pages = 368-73 | month = Feb | year = 2008 | doi = 10.1097/HJH.0b013e3282f283f3 | PMID = 18192852 }}</ref>

Revision as of 04:36, 9 November 2014

Juxtaglomerular cell tumour, abbreviated JCT, is a rare kidney tumour associated with hypertension and typically seen in adolescents or young adults.

It is also known as juxtaglomerular tumour and reninoma.[1]

General

  • Rare.
  • Etiology: increased renin.
  • Typically adolescents or young adults.[2]

Clinical:[1]

  • Hypertension.
  • Increased aldosterone.
    • Causes hypokalemia.
  • Increased plasma renin.

Microscopic

Features:[3]

  • Polygonal cells.
  • Abundant granular, eosinophilic cytoplasm.[4]
  • Perinuclear halo.

DDx:[2]

Images

Stains

Cytoplasmic granules.[4]

  • PAS +ve.
  • PASD +ve.

IHC

Features:

  • CD34 +ve.[2]
  • Vimentin +ve.
  • Actin +ve.
  • Cytokeratin -ve.[3]
  • HMB-45 -ve.[3]

Others:[2]

  • CD31 -ve.
  • Desmin -ve.
  • S-100 -ve.
  • Chromogranin -ve.
  • Synaptophysin -ve.
  • NSE -ve.

EM

Features:

  • Vesicles - contain renin.[5]

See also

References

  1. ↑ 1.0 1.1 Wong, L.; Hsu, TH.; Perlroth, MG.; Hofmann, LV.; Haynes, CM.; Katznelson, L. (Feb 2008). "Reninoma: case report and literature review.". J Hypertens 26 (2): 368-73. doi:10.1097/HJH.0b013e3282f283f3. PMID 18192852.
  2. ↑ 2.0 2.1 2.2 2.3 2.4 2.5 Kuroda, N.; Gotoda, H.; Ohe, C.; Mikami, S.; Inoue, K.; Nagashima, Y.; Petersson, F.; Alvarado-Cabrero, I. et al. (2011). "Review of juxtaglomerular cell tumor with focus on pathobiological aspect.". Diagn Pathol 6: 80. doi:10.1186/1746-1596-6-80. PMID 21871063.
  3. ↑ 3.0 3.1 3.2 3.3 Chao, CT.; Chang, FC.; Wu, VC.; Chen, JC. (Jan 2011). "Reninoma.". Kidney Int 79 (2): 260. doi:10.1038/ki.2010.445. PMID 21191395.
  4. ↑ 4.0 4.1 Hanna, W.; Tepperman, B.; Logan, AG.; Robinette, MA.; Colapinto, R.; Phillips, MJ. (Apr 1979). "Juxtaglomerular cell tumour (reninoma) with paroxysmal hypertension.". Can Med Assoc J 120 (8): 957-9. PMID PMC = 1819229 436071 PMC = 1819229.
  5. ↑ URL: http://path.upmc.edu/cases/case29/micro.html. Accessed on: 18 December 2011.
Retrieved from "https://librepathology.org/w/index.php?title=Juxtaglomerular_cell_tumour&oldid=34732"