Difference between revisions of "Juxtaglomerular cell tumour"

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===Images===
===Images===
*[http://www.nature.com/ki/journal/v79/n2/fig_tab/ki2010445f1.html#figure-title Reninoma (nature.com)].<ref name=pmid21191395/>
*[http://www.nature.com/ki/journal/v79/n2/fig_tab/ki2010445f1.html#figure-title Reninoma (nature.com)].<ref name=pmid21191395/>
*[http://www.diagnosticpathology.org/content/6/1/80/figure/F2 JCT (diagnosticpathology.org)].<ref name=pmid21871063/>
*[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3173291/figure/F1/ JCT (nih.gov)].<ref name=pmid21871063/>
*[http://www.diagnosticpathology.org/content/6/1/80/figure/F1 JCT (diagnosticpathology.org)].<ref name=pmid21871063>{{Cite journal  | last1 = Kuroda | first1 = N. | last2 = Gotoda | first2 = H. | last3 = Ohe | first3 = C. | last4 = Mikami | first4 = S. | last5 = Inoue | first5 = K. | last6 = Nagashima | first6 = Y. | last7 = Petersson | first7 = F. | last8 = Alvarado-Cabrero | first8 = I. | last9 = Pan | first9 = CC. | title = Review of juxtaglomerular cell tumor with focus on pathobiological aspect. | journal = Diagn Pathol | volume = 6 | issue =  | pages = 80 | month =  | year = 2011 | doi = 10.1186/1746-1596-6-80 | PMID = 21871063 }}</ref>
*[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3173291/figure/F2/ JCT (nih.gov)].<ref name=pmid21871063>{{Cite journal  | last1 = Kuroda | first1 = N. | last2 = Gotoda | first2 = H. | last3 = Ohe | first3 = C. | last4 = Mikami | first4 = S. | last5 = Inoue | first5 = K. | last6 = Nagashima | first6 = Y. | last7 = Petersson | first7 = F. | last8 = Alvarado-Cabrero | first8 = I. | last9 = Pan | first9 = CC. | title = Review of juxtaglomerular cell tumor with focus on pathobiological aspect. | journal = Diagn Pathol | volume = 6 | issue =  | pages = 80 | month =  | year = 2011 | doi = 10.1186/1746-1596-6-80 | PMID = 21871063 }}</ref>


==Stains==
==Stains==

Revision as of 04:27, 9 November 2014

Juxtaglomerular cell tumour, abbreviated JCT, is a rare kidney tumour.

It is also known as juxtaglomerular tumour and reninoma.[1]

General

  • Rare.
  • Etiology: increased renin.

Clinical:[1]

  • Hypertension.
  • Increased aldosterone.
    • Causes hypokalemia.
  • Increased plasma renin.

Microscopic

Features:[2]

  • Polygonal cells.
  • Abundant granular, eosinophilic cytoplasm.[3]
  • Perinuclear halo.

DDx:

Images

Stains

Cytoplasmic granules.[3]

  • PAS +ve.
  • PASD +ve.

IHC

Features:[2]

  • Actin +ve.
  • Cytokeratin -ve.
  • HMB-45 -ve.

EM

Features:

  • Vesicles - contain renin.[5]

See also

References

  1. ↑ 1.0 1.1 Wong, L.; Hsu, TH.; Perlroth, MG.; Hofmann, LV.; Haynes, CM.; Katznelson, L. (Feb 2008). "Reninoma: case report and literature review.". J Hypertens 26 (2): 368-73. doi:10.1097/HJH.0b013e3282f283f3. PMID 18192852.
  2. ↑ 2.0 2.1 2.2 Chao, CT.; Chang, FC.; Wu, VC.; Chen, JC. (Jan 2011). "Reninoma.". Kidney Int 79 (2): 260. doi:10.1038/ki.2010.445. PMID 21191395.
  3. ↑ 3.0 3.1 Hanna, W.; Tepperman, B.; Logan, AG.; Robinette, MA.; Colapinto, R.; Phillips, MJ. (Apr 1979). "Juxtaglomerular cell tumour (reninoma) with paroxysmal hypertension.". Can Med Assoc J 120 (8): 957-9. PMID PMC = 1819229 436071 PMC = 1819229.
  4. ↑ 4.0 4.1 Kuroda, N.; Gotoda, H.; Ohe, C.; Mikami, S.; Inoue, K.; Nagashima, Y.; Petersson, F.; Alvarado-Cabrero, I. et al. (2011). "Review of juxtaglomerular cell tumor with focus on pathobiological aspect.". Diagn Pathol 6: 80. doi:10.1186/1746-1596-6-80. PMID 21871063.
  5. ↑ URL: http://path.upmc.edu/cases/case29/micro.html. Accessed on: 18 December 2011.
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