Difference between revisions of "Juvenile granulosa cell tumour"

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| Rads      =
| Endoscopy  =
| Endoscopy  =
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| Prognosis  = good to moderate (dependent on stage)
| Other      =
| Other      =
| ClinDDx    =
| ClinDDx    =
| Tx        =
| Tx        = surgery
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'''Juvenile granulosa cell tumour''' is an uncommon [[ovarian tumour]] in the ''sex cord stromal tumours'' group.
'''Juvenile granulosa cell tumour''' is an uncommon [[ovarian tumour]] in the ''sex cord stromal tumours'' group.

Revision as of 03:58, 18 February 2014

Juvenile granulosa cell tumour
Diagnosis in short

Juvenile granulosa cell tumour. H&E stain.

LM microcystic spaces, cuboidal-to-polygonal cells in sheets or stands or cords, with moderate-to-marked nuclear atypia, and basophilic cytoplasm
LM DDx Brenner tumour
IHC inhibin +ve, calretinin +ve
Gross mass lesion, solid
Site ovary - ovarian tumours

Associated Dx endometrial hyperplasia, endometrioid endometrial carcinoma
Symptoms +/-menorrhagia
Prevalence uncommon
Prognosis good to moderate (dependent on stage)
Treatment surgery

Juvenile granulosa cell tumour is an uncommon ovarian tumour in the sex cord stromal tumours group.

General

Gross

  • Classically solid.

Microscopic

Features:

  • Microcystic spaces.
  • Moderate-to-marked nuclear atypia.
  • Cuboidal-to-polygonal cell in sheets or stands or cords.
  • Basophilic cytoplasm.

Notes:

  • Juvenile variant of GCT has more nuclear pleomorphism.

DDx:

Images

IHC

Molecular

Currently not used for the diagnosis.

See also

References

  1. Hashemipour, M.; Moaddab, MH.; Nazem, M.; Mahzouni, P.; Salek, M. (Jul 2010). "Granulosa cell tumor in a six-year-old girl presented as precocious puberty.". J Res Med Sci 15 (4): 240-2. PMID 21526089.
  2. URL: http://path.upmc.edu/cases/case631.html. Accessed on: 26 January 2012.
  3. Oztekin, D.; Kurt, S.; Camuzcuoglu, H.; Balsak, D.; Dicle, N.; Tinar, S.. "Granulosa cell tumors of the ovary: review of 43 cases.". J BUON 17 (3): 461-4. PMID 23033282.
  4. Cotran, Ramzi S.; Kumar, Vinay; Fausto, Nelson; Nelso Fausto; Robbins, Stanley L.; Abbas, Abul K. (2005). Robbins and Cotran pathologic basis of disease (7th ed.). St. Louis, Mo: Elsevier Saunders. pp. 1102. ISBN 0-7216-0187-1.
  5. Schofield, DE.; Fletcher, JA. (Dec 1992). "Trisomy 12 in pediatric granulosa-stromal cell tumors. Demonstration by a modified method of fluorescence in situ hybridization on paraffin-embedded material.". Am J Pathol 141 (6): 1265-9. PMID 1466394.
  6. Mayr, D.; Kaltz-Wittmer, C.; Arbogast, S.; Amann, G.; Aust, DE.; Diebold, J. (Sep 2002). "Characteristic pattern of genetic aberrations in ovarian granulosa cell tumors.". Mod Pathol 15 (9): 951-7. doi:10.1097/01.MP.0000024290.55261.14. PMID 12218213.