Difference between revisions of "Juvenile granulosa cell tumour"
Jump to navigation
Jump to search
(split out) |
|||
| Line 1: | Line 1: | ||
{{ Infobox diagnosis | |||
| Name = {{PAGENAME}} | |||
| Image = Juvenile_granulosa_cell_tumour_-_very_high_mag.jpg | |||
| Width = | |||
| Caption = Juvenile granulosa cell tumour. [[H&E stain]]. | |||
| Synonyms = | |||
| Micro = microcystic spaces, cuboidal-to-polygonal cells in sheets or stands or cords, with moderate-to-marked nuclear atypia, and basophilic cytoplasm | |||
| Subtypes = | |||
| LMDDx = [[Brenner tumour]] | |||
| Stains = | |||
| IHC = inhibin +ve, calretinin +ve | |||
| EM = | |||
| Molecular = | |||
| IF = | |||
| Gross = mass lesion, solid | |||
| Grossing = | |||
| Site = [[ovary]] - ''[[ovarian tumours]]'' | |||
| Assdx = [[endometrial hyperplasia]], [[endometrioid endometrial carcinoma]] | |||
| Syndromes = | |||
| Clinicalhx = | |||
| Signs = | |||
| Symptoms = +/-menorrhagia | |||
| Prevalence = uncommon | |||
| Bloodwork = | |||
| Rads = | |||
| Endoscopy = | |||
| Prognosis = | |||
| Other = | |||
| ClinDDx = | |||
| Tx = | |||
}} | |||
'''Juvenile granulosa cell tumour''' is an uncommon [[ovarian tumour]] in the ''sex cord stromal tumours'' group. | '''Juvenile granulosa cell tumour''' is an uncommon [[ovarian tumour]] in the ''sex cord stromal tumours'' group. | ||
| Line 6: | Line 37: | ||
**May present as precocious puberty.<ref name=pmid21526089>{{Cite journal | last1 = Hashemipour | first1 = M. | last2 = Moaddab | first2 = MH. | last3 = Nazem | first3 = M. | last4 = Mahzouni | first4 = P. | last5 = Salek | first5 = M. | title = Granulosa cell tumor in a six-year-old girl presented as precocious puberty. | journal = J Res Med Sci | volume = 15 | issue = 4 | pages = 240-2 | month = Jul | year = 2010 | doi = | PMID = 21526089 }}</ref> | **May present as precocious puberty.<ref name=pmid21526089>{{Cite journal | last1 = Hashemipour | first1 = M. | last2 = Moaddab | first2 = MH. | last3 = Nazem | first3 = M. | last4 = Mahzouni | first4 = P. | last5 = Salek | first5 = M. | title = Granulosa cell tumor in a six-year-old girl presented as precocious puberty. | journal = J Res Med Sci | volume = 15 | issue = 4 | pages = 240-2 | month = Jul | year = 2010 | doi = | PMID = 21526089 }}</ref> | ||
*Reported in males.<ref>URL: [http://path.upmc.edu/cases/case631.html http://path.upmc.edu/cases/case631.html]. Accessed on: 26 January 2012.</ref> | *Reported in males.<ref>URL: [http://path.upmc.edu/cases/case631.html http://path.upmc.edu/cases/case631.html]. Accessed on: 26 January 2012.</ref> | ||
*Uncommon.<ref name=pmid23033282>{{Cite journal | last1 = Oztekin | first1 = D. | last2 = Kurt | first2 = S. | last3 = Camuzcuoglu | first3 = H. | last4 = Balsak | first4 = D. | last5 = Dicle | first5 = N. | last6 = Tinar | first6 = S. | title = Granulosa cell tumors of the ovary: review of 43 cases. | journal = J BUON | volume = 17 | issue = 3 | pages = 461-4 | month = | year = | doi = | PMID = 23033282 }}</ref> | |||
==Gross== | ==Gross== | ||
| Line 19: | Line 51: | ||
Notes: | Notes: | ||
*Juvenile variant of GCT has more nuclear pleomorphism. | *Juvenile variant of GCT has more nuclear pleomorphism. | ||
DDx: | |||
*[[Brenner tumour]]. | |||
===Images=== | ===Images=== | ||
Revision as of 03:56, 18 February 2014
| Juvenile granulosa cell tumour | |
|---|---|
| Diagnosis in short | |
 Juvenile granulosa cell tumour. H&E stain. | |
|
| |
| LM | microcystic spaces, cuboidal-to-polygonal cells in sheets or stands or cords, with moderate-to-marked nuclear atypia, and basophilic cytoplasm |
| LM DDx | Brenner tumour |
| IHC | inhibin +ve, calretinin +ve |
| Gross | mass lesion, solid |
| Site | ovary - ovarian tumours |
|
| |
| Associated Dx | endometrial hyperplasia, endometrioid endometrial carcinoma |
| Symptoms | +/-menorrhagia |
| Prevalence | uncommon |
Juvenile granulosa cell tumour is an uncommon ovarian tumour in the sex cord stromal tumours group.
General
- May secrete estrogen.
- May present with endometrial pathology, e.g. endometrial hyperplasia or endometrioid endometrial carcinoma.
- May present as precocious puberty.[1]
- Reported in males.[2]
- Uncommon.[3]
Gross
- Classically solid.
Microscopic
Features:
- Microcystic spaces.
- Moderate-to-marked nuclear atypia.
- Cuboidal-to-polygonal cell in sheets or stands or cords.
- Basophilic cytoplasm.
Notes:
- Juvenile variant of GCT has more nuclear pleomorphism.
DDx:
Images
Juvenile granulosa cell tumour - intermed. mag. (WC)
Juvenile granulosa cell tumour - high mag. (WC)
Juvenile granulosa cell tumour - very high mag. (WC)
IHC
- Inhibin positive.[4]
- Inhibin negative in Brenner tumour.
- Calretinin +ve.
Molecular
- Currently not used for the diagnosis.
See also
References
- ↑ Hashemipour, M.; Moaddab, MH.; Nazem, M.; Mahzouni, P.; Salek, M. (Jul 2010). "Granulosa cell tumor in a six-year-old girl presented as precocious puberty.". J Res Med Sci 15 (4): 240-2. PMID 21526089.
- ↑ URL: http://path.upmc.edu/cases/case631.html. Accessed on: 26 January 2012.
- ↑ Oztekin, D.; Kurt, S.; Camuzcuoglu, H.; Balsak, D.; Dicle, N.; Tinar, S.. "Granulosa cell tumors of the ovary: review of 43 cases.". J BUON 17 (3): 461-4. PMID 23033282.
- ↑ Cotran, Ramzi S.; Kumar, Vinay; Fausto, Nelson; Nelso Fausto; Robbins, Stanley L.; Abbas, Abul K. (2005). Robbins and Cotran pathologic basis of disease (7th ed.). St. Louis, Mo: Elsevier Saunders. pp. 1102. ISBN 0-7216-0187-1.
- ↑ Schofield, DE.; Fletcher, JA. (Dec 1992). "Trisomy 12 in pediatric granulosa-stromal cell tumors. Demonstration by a modified method of fluorescence in situ hybridization on paraffin-embedded material.". Am J Pathol 141 (6): 1265-9. PMID 1466394.
- ↑ Mayr, D.; Kaltz-Wittmer, C.; Arbogast, S.; Amann, G.; Aust, DE.; Diebold, J. (Sep 2002). "Characteristic pattern of genetic aberrations in ovarian granulosa cell tumors.". Mod Pathol 15 (9): 951-7. doi:10.1097/01.MP.0000024290.55261.14. PMID 12218213.