Difference between revisions of "Intranodal palisaded myofibroblastoma"

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Line 5: Line 5:
*Male:female = 2:1.
*Male:female = 2:1.
*Adults - middle age.
*Adults - middle age.
*Recurrence is reported<ref name=pmid10235504>{{Cite journal  | last1 = Creager | first1 = AJ. | last2 = Garwacki | first2 = CP. | title = Recurrent intranodal palisaded myofibroblastoma with metaplastic bone formation. | journal = Arch Pathol Lab Med | volume = 123 | issue = 5 | pages = 433-6 | month = May | year = 1999 | doi = 10.1043/0003-9985(1999)1230433:RIPMWM2.0.CO;2 | PMID = 10235504 }}</ref>... but considered very rare.


==Microscopic==
==Microscopic==

Revision as of 23:05, 9 October 2011

Intranodal palisaded myofibroblastoma, abbreviated IPM, is a rare tumour that classically presents as an inguinal mass.[1]

General

  • Rare.
  • Male:female = 2:1.
  • Adults - middle age.
  • Recurrence is reported[2]... but considered very rare.

Microscopic

Features:

  1. Rim of peripheral lymphoid tissue.
  2. Spindle cells with nuclear palisading - key feature.
  3. RBC extravasation/hemorrhage.
  4. Amianthoid fibers - blood vessel surrounded by collagen with (fine) peripheral spokes.[3]
  5. Intracellular and extracellular fuchsinophilic bodies.
    • Smooth muscle actin +ve.

DDx:

Notes:

Images:

IHC

  • SMA +ve.
  • Cyclin D1 +ve.

Other:

  • S100 -ve
  • GFAP -ve.
  • CD34 -ve.
  • Desmin -ve
  • Ki-67 - low.

See also

References

  1. Nguyen, T.; Eltorky, MA. (Feb 2007). "Intranodal palisaded myofibroblastoma.". Arch Pathol Lab Med 131 (2): 306-10. doi:10.1043/1543-2165(2007)131[306:IPM]2.0.CO;2. PMID 17284119.
  2. Creager, AJ.; Garwacki, CP. (May 1999). "Recurrent intranodal palisaded myofibroblastoma with metaplastic bone formation.". Arch Pathol Lab Med 123 (5): 433-6. doi:10.1043/0003-9985(1999)1230433:RIPMWM2.0.CO;2. PMID 10235504.
  3. 3.0 3.1 Bigotti, G.; Coli, A.; Mottolese, M.; Di Filippo, F. (Sep 1991). "Selective location of palisaded myofibroblastoma with amianthoid fibres.". J Clin Pathol 44 (9): 761-4. PMID 1918406.
  4. URL: http://www.merriam-webster.com/medical/fuchsinophilic. Accessed on: 3 October 2011.