Difference between revisions of "Intranodal palisaded myofibroblastoma"

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Features:
Features:
#Rim of peripheral lymphoid tissue.
#Rim of peripheral lymphoid tissue.
#spindle cells with nuclear palisading
#Spindle cells with nuclear palisading - '''key feature'''.
#RBC extravasation/hemorrhage.
#RBC extravasation/hemorrhage.
#Amianthoid fibers - blood vessel surrounded by collagen with peripheral spokes.<ref name=pmid1918406>{{Cite journal  | last1 = Bigotti | first1 = G. | last2 = Coli | first2 = A. | last3 = Mottolese | first3 = M. | last4 = Di Filippo | first4 = F. | title = Selective location of palisaded myofibroblastoma with amianthoid fibres. | journal = J Clin Pathol | volume = 44 | issue = 9 | pages = 761-4 | month = Sep | year = 1991 | doi =  | PMID = 1918406 }}</ref>
#Amianthoid fibers - blood vessel surrounded by collagen with peripheral spokes.<ref name=pmid1918406>{{Cite journal  | last1 = Bigotti | first1 = G. | last2 = Coli | first2 = A. | last3 = Mottolese | first3 = M. | last4 = Di Filippo | first4 = F. | title = Selective location of palisaded myofibroblastoma with amianthoid fibres. | journal = J Clin Pathol | volume = 44 | issue = 9 | pages = 761-4 | month = Sep | year = 1991 | doi =  | PMID = 1918406 }}</ref>
#intracellular and extracellular fuchsinophilic bodies that stain positive for smooth muscle actin.
#Intracellular and extracellular fuchsinophilic bodies.
#*Smooth muscle actin.


DDx:
DDx:

Revision as of 03:34, 4 October 2011

Intranodal palisaded myofibroblastoma, abbreviated IPM, is a rare tumour that classically presents as an inguinal mass.[1]

General

  • Rare.
  • Male:female = 2:1.
  • Adults - middle age.

Microscopic

Features:

  1. Rim of peripheral lymphoid tissue.
  2. Spindle cells with nuclear palisading - key feature.
  3. RBC extravasation/hemorrhage.
  4. Amianthoid fibers - blood vessel surrounded by collagen with peripheral spokes.[2]
  5. Intracellular and extracellular fuchsinophilic bodies.
    • Smooth muscle actin.

DDx:

Images:

IHC

  • SMA +ve.
  • Cyclin D1 +ve.

Other:

  • S100 -ve
  • GFAP -ve.
  • CD34 -ve.
  • Desmin -ve
  • Ki-67 - low.

See also

References

  1. Nguyen, T.; Eltorky, MA. (Feb 2007). "Intranodal palisaded myofibroblastoma.". Arch Pathol Lab Med 131 (2): 306-10. doi:10.1043/1543-2165(2007)131[306:IPM]2.0.CO;2. PMID 17284119.
  2. 2.0 2.1 Bigotti, G.; Coli, A.; Mottolese, M.; Di Filippo, F. (Sep 1991). "Selective location of palisaded myofibroblastoma with amianthoid fibres.". J Clin Pathol 44 (9): 761-4. PMID 1918406.