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Difference between revisions of "Intestinal metaplasia of the stomach"
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Intestinal metaplasia of the stomach (view source)
Revision as of 12:56, 3 May 2016
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{{ Infobox diagnosis | {{ Infobox diagnosis | ||
| Name = {{PAGENAME}} | | Name = {{PAGENAME}} | ||
| Image = | | Image = Stomach with intestinal metaplasia -- intermed mag.jpg | ||
| Width = | | Width = | ||
| Caption = Intestinal metaplasia of the stomach. [[H&E stain]]. | | Caption = Intestinal metaplasia of the stomach. [[H&E stain]]. | ||
| Micro = goblet cells with foveolar epithelium | | Micro = goblet cells with foveolar epithelium | ||
| Subtypes = | | Subtypes = | ||
| LMDDx = contaminant from the [[duodenum]], [[gastric dysplasia]], [[gastric carcinoma]] | | LMDDx = contaminant from the [[duodenum]], [[gastric dysplasia]], [[gastric carcinoma]], [[gastric heterotopia of the duodenum]] | ||
| Stains = alcian blue/PAS +ve | | Stains = alcian blue/PAS +ve | ||
| IHC = CDX2 +ve | | IHC = CDX2 +ve | ||
| Line 30: | Line 30: | ||
{{ Infobox external links | {{ Infobox external links | ||
| Name = {{PAGENAME}} | | Name = {{PAGENAME}} | ||
| EHVSC = 10167 | | EHVSC = | ||
| EHVSC_mult = {{EHVSC3|10167|focal}} | |||
| pathprotocols = | | pathprotocols = | ||
| wikipedia = | | wikipedia = | ||
| Line 69: | Line 70: | ||
DDx: | DDx: | ||
*[[Normal duodenum|Normal small bowel mucosa]] - no foveolar epithelium present. | *[[Normal duodenum|Normal small bowel mucosa]] - no foveolar epithelium present, possibly a contaminant from a concurrent duodenal biopsy. | ||
*[[Gastric dysplasia]], intestinal type. | *[[Gastric dysplasia]], intestinal type. | ||
*[[Gastric heterotopia of the duodenum]]. | |||
===Images=== | ===Images=== | ||
<gallery> | <gallery> | ||
Image: | Image: Stomach with intestinal metaplasia -- intermed mag.jpg | Stomach IM - intermed. mag. (WC) | ||
Image: Stomach with intestinal metaplasia -- high mag.jpg | Stomach IM - high mag. (WC) | |||
</gallery> | </gallery> | ||
==Stains== | ==Stains== | ||
*Alcian blue (pH 2.5)/PAS +ve.<ref name=pmid14736279>{{Cite journal | last1 = Rivera-Hueto | first1 = F. | last2 = Lag-Asturiano | first2 = E. | last3 = Utrilla-Alcolea | first3 = JC. | last4 = Herrerías-Gutiérrez | first4 = JM. | title = Advanced gastric carcinoma with a complete intestinal metaplasia phenotype associated with early intestinal-type carcinoma. | journal = Arch Pathol Lab Med | volume = 128 | issue = 2 | pages = 218-21 | month = Feb | year = 2004 | doi = 10.1043/1543-2165(2004)128218:AGCWAC2.0.CO;2 | PMID = 14736279 }}</ref> | *Alcian blue (pH 2.5)/PAS +ve.<ref name=pmid14736279>{{Cite journal | last1 = Rivera-Hueto | first1 = F. | last2 = Lag-Asturiano | first2 = E. | last3 = Utrilla-Alcolea | first3 = JC. | last4 = Herrerías-Gutiérrez | first4 = JM. | title = Advanced gastric carcinoma with a complete intestinal metaplasia phenotype associated with early intestinal-type carcinoma. | journal = Arch Pathol Lab Med | volume = 128 | issue = 2 | pages = 218-21 | month = Feb | year = 2004 | doi = 10.1043/1543-2165(2004)128218:AGCWAC2.0.CO;2 | PMID = 14736279 }}</ref> | ||
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</gallery> | </gallery> | ||
==IHC== | ==IHC== | ||
*CDX2 +ve (-ve in normal stomach).<ref name=pmid12477745 | *CDX2 +ve (-ve in normal stomach).<ref name=pmid12477745/> | ||
**Strong assoc. with ''[[Helicobacter gastritis]]'' as well as IM.<ref name=pmid12047325>{{Cite journal | last1 = Satoh | first1 = K. | last2 = Mutoh | first2 = H. | last3 = Eda | first3 = A. | last4 = Yanaka | first4 = I. | last5 = Osawa | first5 = H. | last6 = Honda | first6 = S. | last7 = Kawata | first7 = H. | last8 = Kihira | first8 = K. | last9 = Sugano | first9 = K. | title = Aberrant expression of CDX2 in the gastric mucosa with and without intestinal metaplasia: effect of eradication of Helicobacter pylori. | journal = Helicobacter | volume = 7 | issue = 3 | pages = 192-8 | month = Jun | year = 2002 | doi = | PMID = 12047325 }}</ref> | **Strong assoc. with ''[[Helicobacter gastritis]]'' as well as IM.<ref name=pmid12047325>{{Cite journal | last1 = Satoh | first1 = K. | last2 = Mutoh | first2 = H. | last3 = Eda | first3 = A. | last4 = Yanaka | first4 = I. | last5 = Osawa | first5 = H. | last6 = Honda | first6 = S. | last7 = Kawata | first7 = H. | last8 = Kihira | first8 = K. | last9 = Sugano | first9 = K. | title = Aberrant expression of CDX2 in the gastric mucosa with and without intestinal metaplasia: effect of eradication of Helicobacter pylori. | journal = Helicobacter | volume = 7 | issue = 3 | pages = 192-8 | month = Jun | year = 2002 | doi = | PMID = 12047325 }}</ref> | ||
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==Sign out== | ==Sign out== | ||
===Focal=== | |||
<pre> | |||
Stomach, Antrum, Biopsy: | |||
- Antral-type gastric mucosa with intestinal metaplasia (focal) and | |||
moderate chronic inactive inflammation. | |||
- NEGATIVE for Helicobacter-like organisms. | |||
- NEGATIVE for dysplasia and NEGATIVE for malignancy. | |||
</pre> | |||
====Block letters==== | |||
<pre> | <pre> | ||
STOMACH, BIOPSY: | STOMACH, BIOPSY: | ||
- BODY-TYPE MUCOSA WITH INTESTINAL METAPLASIA, FOCAL. | - BODY-TYPE GASTRIC MUCOSA WITH INTESTINAL METAPLASIA, FOCAL. | ||
- MINIMAL CHRONIC GASTRITIS (BODY OF STOMACH). | - MINIMAL CHRONIC GASTRITIS (BODY OF STOMACH). | ||
- NEGATIVE FOR HELICOBACTER-LIKE ORGANISMS. | - NEGATIVE FOR HELICOBACTER-LIKE ORGANISMS. | ||
| Line 104: | Line 117: | ||
<pre> | <pre> | ||
STOMACH, BIOPSY: | STOMACH, BIOPSY: | ||
- ANTRAL-TYPE MUCOSA WITH INTESTINAL METAPLASIA | - ANTRAL-TYPE GASTRIC MUCOSA WITH FOCAL INTESTINAL METAPLASIA AND MILD CHRONIC | ||
INACTIVE INFLAMMATION. | |||
- NEGATIVE FOR HELICOBACTER-LIKE ORGANISMS. | - NEGATIVE FOR HELICOBACTER-LIKE ORGANISMS. | ||
- NEGATIVE FOR DYSPLASIA AND NEGATIVE FOR MALIGNANCY. | - NEGATIVE FOR DYSPLASIA AND NEGATIVE FOR MALIGNANCY. | ||
</pre> | </pre> | ||
===Extensive=== | |||
<pre> | <pre> | ||
STOMACH, BIOPSY: | STOMACH, BIOPSY: | ||