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Difference between revisions of "Intestinal metaplasia of the gallbladder"
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Intestinal metaplasia of the gallbladder (view source)
Revision as of 18:34, 2 June 2017
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| Molecular = | | Molecular = | ||
| IF = | | IF = | ||
| Gross = | | Gross = | ||
| Grossing = | | Grossing = [[Gallbladder grossing]] | ||
| Site = [[gallbladder]] | | Site = [[gallbladder]] | ||
| Assdx = [[chronic cholecystitis]] | | Assdx = [[chronic cholecystitis]] | ||
| Line 42: | Line 42: | ||
*No specific changes. | *No specific changes. | ||
Notes: | |||
*Usually seen in the context of chronic cholecystitis if isolated. | *Usually seen in the context of chronic cholecystitis if isolated. | ||
| Line 48: | Line 48: | ||
Features:<ref name=pmid2872152>{{Cite journal | last1 = Albores-Saavedra | first1 = J. | last2 = Nadji | first2 = M. | last3 = Henson | first3 = DE. | last4 = Ziegels-Weissman | first4 = J. | last5 = Mones | first5 = JM. | title = Intestinal metaplasia of the gallbladder: a morphologic and immunocytochemical study. | journal = Hum Pathol | volume = 17 | issue = 6 | pages = 614-20 | month = Jun | year = 1986 | doi = | PMID = 2872152 }}</ref> | Features:<ref name=pmid2872152>{{Cite journal | last1 = Albores-Saavedra | first1 = J. | last2 = Nadji | first2 = M. | last3 = Henson | first3 = DE. | last4 = Ziegels-Weissman | first4 = J. | last5 = Mones | first5 = JM. | title = Intestinal metaplasia of the gallbladder: a morphologic and immunocytochemical study. | journal = Hum Pathol | volume = 17 | issue = 6 | pages = 614-20 | month = Jun | year = 1986 | doi = | PMID = 2872152 }}</ref> | ||
*[[Goblet cell]]s - '''key feature'''. | *[[Goblet cell]]s - '''key feature'''. | ||
*+/-Paneth | *+/-[[Paneth cell]]s.<ref name=Ref_Sternberg4_1789>{{Ref Sternberg4|1789}}</ref> | ||
Notes: | |||
*Often accompanied by antral type metplasia. | *Often accompanied by antral type metplasia. | ||
**Gastric antral-type epithelium - may form glands. | **Gastric antral-type epithelium - may form glands. | ||
*Gallbladders with intestinal metaplasia do ''not'' have to be [[submitted in total]].<ref name=uscap2017_akki>Akki ''et al.'' (2017) "Detecting Incidental Gallbladder Adenocarcinoma: When to Submit the Entire Gallbladder". Available at: [http://www.abstracts2view.com/uscap17/view.php?nu=USCAP17L_2016 http://www.abstracts2view.com/uscap17/view.php?nu=USCAP17L_2016]. United States and Canadian Academy of Pathology Annual Meeting. Accessed on: April 9, 2017.</ref> | |||
DDx: | DDx: | ||
*[[Gallbladder adenocarcinoma]]. | *[[Gallbladder adenocarcinoma]]. | ||
*[[Gallbladder adenoma]] (gallbladder dysplasia). | |||
===Images=== | ===Images=== | ||
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==Sign out== | ==Sign out== | ||
<pre> | |||
Gallbladder, Cholecystectomy: | |||
- Gallbladder wall with focal intestinal metaplasia and mild chronic inflammation. | |||
- Cholelithiasis. | |||
- NEGATIVE for dysplasia. | |||
</pre> | |||
===Block letters=== | |||
<pre> | <pre> | ||
GALLBLADDER, CHOLECYSTECTOMY: | GALLBLADDER, CHOLECYSTECTOMY: | ||
| Line 77: | Line 87: | ||
- NEGATIVE FOR DYSPLASIA. | - NEGATIVE FOR DYSPLASIA. | ||
</pre> | </pre> | ||
===Micro=== | |||
The sections show gallbladder wall with mild chronic inflammation and entrapped epithelial | |||
crypts, that focally extend through the muscularis. The entrapped deep crypts have no | |||
apparent nuclear atypia, and no apparent mitotic activity. | |||
A very small focus of intestinal metaplasia is present in the surface epithelium. No dysplasia is identified. | |||
==See also== | ==See also== | ||