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Difference between revisions of "Inflammatory fibroid polyp"
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{{ Infobox diagnosis | |||
| Name = {{PAGENAME}} | |||
| Image = Inflammatory_fibroid_polyp_-_low_mag.jpg | |||
| Width = | |||
| Caption = Inflammatory fibroid polyp. [[H&E stain]]. | |||
| Micro = proliferating spindle cells - loosely arranged round blood vessels with perivascular hypocellular zones, eosinophils (common), leiomyoma/schwannoma-like areas - with nuclear palisading | |||
| Subtypes = | |||
| LMDDx = [[inflammatory myofibroblastic tumour]], [[GIST]], [[schwannoma]] | |||
| Stains = | |||
| IHC = CD34 +ve, vimentin +ve, CD117 -ve, S-100 -ve | |||
| EM = | |||
| Molecular = | |||
| IF = | |||
| Gross = | |||
| Grossing = | |||
| Site = [[stomach]], other places in the GI tract | |||
| Assdx = | |||
| Syndromes = | |||
| Clinicalhx = | |||
| Signs = | |||
| Symptoms = | |||
| Prevalence = | |||
| Bloodwork = | |||
| Rads = | |||
| Endoscopy = | |||
| Prognosis = good - benign | |||
| Other = | |||
| ClinDDx = | |||
}} | |||
'''Inflammatory fibroid polyp''' is an uncommon [[gastrointestinal polyp]]. | |||
==General== | |||
*Benign. | |||
*Through-out GI tract. | |||
*Can be thought of as granulation tissue-like.<ref name=Ref_DCHH138/> | |||
==Microscopic== | |||
Features:<ref name=pmid20393746>{{Cite journal | last1 = Daum | first1 = O. | last2 = Hatlova | first2 = J. | last3 = Mandys | first3 = V. | last4 = Grossmann | first4 = P. | last5 = Mukensnabl | first5 = P. | last6 = Benes | first6 = Z. | last7 = Michal | first7 = M. | title = Comparison of morphological, immunohistochemical, and molecular genetic features of inflammatory fibroid polyps (Vanek's tumors). | journal = Virchows Arch | volume = 456 | issue = 5 | pages = 491-7 | month = May | year = 2010 | doi = 10.1007/s00428-010-0914-8 | PMID = 20393746 }}</ref> | |||
*Proliferating spindle cells (fibroid) - '''key feature'''. | |||
**Loosely arranged, concentrically, around blood vessels.<ref name=Ref_GLP115>{{Ref GLP|115}}</ref> | |||
**Perivascular hypocellular zones.<ref name=Ref_DCHH138>{{Ref DCHH|138}}</ref> | |||
*Inflammation: | |||
**Eosinophils - often prominent. | |||
*+/-Leiomyoma/schwannoma-like areas - with nuclear palisading.<ref name=Ref_DCHH138>{{Ref DCHH|138}}</ref> | |||
*+/-Vascular for fibrous tissue. | |||
*Poorly circumscribed/infiltrates into the lamina propria. | |||
DDx: | |||
*[[Inflammatory myofibroblastic tumour]]. | |||
*[[GIST]] - usually sharply demarcated border. | |||
Notes: | |||
*Concentric = share the same centre.<ref>URL: [http://dictionary.reference.com/browse/concentric http://dictionary.reference.com/browse/concentric]. Accessed on: 29 November 2011.</ref> | |||
===Images=== | |||
<gallery> | |||
Image:Inflammatory_fibroid_polyp_-_low_mag.jpg | IFP - low mag. (WC) | |||
Image:Inflammatory_fibroid_polyp_-_high_mag.jpg | IFP - high mag. (WC) | |||
</gallery> | |||
==IHC== | |||
Features:<ref name=pmid20393746/> | |||
*CD34 +ve. | |||
**There is a CD34 -ve variant. | |||
*Vimentin +ve -- diffuse.<ref>{{Cite journal | last1 = Kolodziejczyk | first1 = P. | last2 = Yao | first2 = T. | last3 = Tsuneyoshi | first3 = M. | title = Inflammatory fibroid polyp of the stomach. A special reference to an immunohistochemical profile of 42 cases. | journal = Am J Surg Pathol | volume = 17 | issue = 11 | pages = 1159-68 | month = Nov | year = 1993 | doi = | PMID = 8214261 }}</ref> | |||
Others: | |||
*CD117 -ve.<ref name=pmid15163021>{{Cite journal | last1 = Ozolek | first1 = JA. | last2 = Sasatomi | first2 = E. | last3 = Swalsky | first3 = PA. | last4 = Rao | first4 = U. | last5 = Krasinskas | first5 = A. | last6 = Finkelstein | first6 = SD. | title = Inflammatory fibroid polyps of the gastrointestinal tract: clinical, pathologic, and molecular characteristics. | journal = Appl Immunohistochem Mol Morphol | volume = 12 | issue = 1 | pages = 59-66 | month = Mar | year = 2004 | doi = | PMID = 15163021 }} | |||
</ref> | |||
*S100 -ve. | |||
==Molecular== | |||
*A subset have mutations in PDGFRA.<ref name=pmid20393746>{{Cite journal | last1 = Daum | first1 = O. | last2 = Hatlova | first2 = J. | last3 = Mandys | first3 = V. | last4 = Grossmann | first4 = P. | last5 = Mukensnabl | first5 = P. | last6 = Benes | first6 = Z. | last7 = Michal | first7 = M. | title = Comparison of morphological, immunohistochemical, and molecular genetic features of inflammatory fibroid polyps (Vanek's tumors). | journal = Virchows Arch | volume = 456 | issue = 5 | pages = 491-7 | month = May | year = 2010 | doi = 10.1007/s00428-010-0914-8 | PMID = 20393746 }}</ref> | |||
==See also== | |||
*[[Stomach]]. | |||
==References== | |||
{{Reflist|2}} | |||
[[Category:Diagnosis]] | [[Category:Diagnosis]] | ||
[[Category:Gastrointestinal pathology]] | |||