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eccrine porocarcinoma,<ref name=pmid26234455>{{Cite journal | last1 = Imafuku | first1 = K. | last2 = Hata | first2 = H. | last3 = Kitamura | first3 = S. | last4 = Iwata | first4 = H. | last5 = Shimizu | first5 = H. | title = In-transit metastasis of advanced eccrine porocarcinoma. | journal = Int J Dermatol | volume = | issue = | pages = | month = Jul | year = 2015 | doi = 10.1111/ijd.12928 | PMID = 26234455 }}</ref> [[Merkel cell carcinoma]].<ref name=pmid25754425>{{Cite journal | last1 = Gunaratne | first1 = DA. | last2 = Howle | first2 = JR. | last3 = Veness | first3 = MJ. | title = Merkel cell carcinoma: A case of palliative upper limb amputation in a patient with refractory in-transit metastases. | journal = Australas J Dermatol | volume = | issue = | pages = | month = Mar | year = 2015 | doi = 10.1111/ajd.12291 | PMID = 25754425 }}</ref> | eccrine porocarcinoma,<ref name=pmid26234455>{{Cite journal | last1 = Imafuku | first1 = K. | last2 = Hata | first2 = H. | last3 = Kitamura | first3 = S. | last4 = Iwata | first4 = H. | last5 = Shimizu | first5 = H. | title = In-transit metastasis of advanced eccrine porocarcinoma. | journal = Int J Dermatol | volume = | issue = | pages = | month = Jul | year = 2015 | doi = 10.1111/ijd.12928 | PMID = 26234455 }}</ref> [[Merkel cell carcinoma]].<ref name=pmid25754425>{{Cite journal | last1 = Gunaratne | first1 = DA. | last2 = Howle | first2 = JR. | last3 = Veness | first3 = MJ. | title = Merkel cell carcinoma: A case of palliative upper limb amputation in a patient with refractory in-transit metastases. | journal = Australas J Dermatol | volume = | issue = | pages = | month = Mar | year = 2015 | doi = 10.1111/ajd.12291 | PMID = 25754425 }}</ref> | ||
''[[Tumour deposits]]'' in [[colorectal adenocarcinoma]], conceptually, are the | ''[[Tumour deposits]]'' in [[colorectal adenocarcinoma]], conceptually, are the same thing as ''in-transit metastases'';<ref name=pmid19136930>{{Cite journal | last1 = Puppa | first1 = G. | last2 = Ueno | first2 = H. | last3 = Kayahara | first3 = M. | last4 = Capelli | first4 = P. | last5 = Canzonieri | first5 = V. | last6 = Colombari | first6 = R. | last7 = Maisonneuve | first7 = P. | last8 = Pelosi | first8 = G. | title = Tumor deposits are encountered in advanced colorectal cancer and other adenocarcinomas: an expanded classification with implications for colorectal cancer staging system including a unifying concept of in-transit metastases. | journal = Mod Pathol | volume = 22 | issue = 3 | pages = 410-5 | month = Mar | year = 2009 | doi = 10.1038/modpathol.2008.198 | PMID = 19136930 }}</ref> however, the details of the definitions are different. | ||
==General== | ==General== | ||
*May be how a tumour (e.g. melanoma<ref name=pmid22329185>{{Cite journal | last1 = Grotz | first1 = TE. | last2 = Mansfield | first2 = AS. | last3 = Kottschade | first3 = LA. | last4 = Erickson | first4 = LA. | last5 = Otley | first5 = CC. | last6 = Markovic | first6 = SN. | last7 = Jakub | first7 = JW. | title = In-transit melanoma: an individualized approach. | journal = Oncology (Williston Park) | volume = 25 | issue = 14 | pages = 1340-8 | month = Dec | year = 2011 | doi = | PMID = 22329185 }}</ref>) recurs. | *It is called "in-transit", as it happens while the tumour is on the way to the regional lymph node. | ||
*May be how a tumour (e.g. melanoma<ref name=pmid22329185>{{Cite journal | last1 = Grotz | first1 = TE. | last2 = Mansfield | first2 = AS. | last3 = Kottschade | first3 = LA. | last4 = Erickson | first4 = LA. | last5 = Otley | first5 = CC. | last6 = Markovic | first6 = SN. | last7 = Jakub | first7 = JW. | title = In-transit melanoma: an individualized approach. | journal = Oncology (Williston Park) | volume = 25 | issue = 14 | pages = 1340-8 | month = Dec | year = 2011 | doi = | PMID = 22329185 }}</ref><ref>{{Cite journal | last1 = Pawlik | first1 = TM. | last2 = Ross | first2 = MI. | last3 = Johnson | first3 = MM. | last4 = Schacherer | first4 = CW. | last5 = McClain | first5 = DM. | last6 = Mansfield | first6 = PF. | last7 = Lee | first7 = JE. | last8 = Cormier | first8 = JN. | last9 = Gershenwald | first9 = JE. | title = Predictors and natural history of in-transit melanoma after sentinel lymphadenectomy. | journal = Ann Surg Oncol | volume = 12 | issue = 8 | pages = 587-96 | month = Aug | year = 2005 | doi = 10.1245/ASO.2005.05.025 | PMID = 16021533 }}</ref>) recurs. | |||
*Poor prognosticator. | *Poor prognosticator. | ||
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#Arises between the nearest (regional) [[lymph node]]s and the primary tumour. | #Arises between the nearest (regional) [[lymph node]]s and the primary tumour. | ||
#*The tumour presumably arises from a lymphatic that drains the tissue in which the primary tumour grew. | #*The tumour presumably arises from a lymphatic that drains the tissue in which the primary tumour grew. | ||
DDx: | DDx: | ||
*Satellitosis. | *[[Satellitosis]] - separate nodule <= 2 cm from the primary tumour. | ||
*[[Lymphovascular invasion]] - does not form a nodule and does not invade into the surround tissue. | *[[Lymphovascular invasion]] - does not form a nodule and does not invade into the surround tissue. | ||
*[[Lymph node metastasis]] - should have lymphoid tissue and capsule ''or'' be round; definitions dependent on the body site/primary tumour. | *[[Lymph node metastasis]] - should have lymphoid tissue and capsule ''or'' be round; definitions dependent on the body site/primary tumour. | ||
*[[Tumour | *[[Tumour deposit]] - also known as ''discoutinuous extramural extension'' and ''peritumoral deposits''; concept in [[colorectal adenocarcinoma]]. | ||
**''Tumour deposits'' conceptually are the samething as the ''in-transit metastases'';<ref name=pmid19136930>{{Cite journal | last1 = Puppa | first1 = G. | last2 = Ueno | first2 = H. | last3 = Kayahara | first3 = M. | last4 = Capelli | first4 = P. | last5 = Canzonieri | first5 = V. | last6 = Colombari | first6 = R. | last7 = Maisonneuve | first7 = P. | last8 = Pelosi | first8 = G. | title = Tumor deposits are encountered in advanced colorectal cancer and other adenocarcinomas: an expanded classification with implications for colorectal cancer staging system including a unifying concept of in-transit metastases. | journal = Mod Pathol | volume = 22 | issue = 3 | pages = 410-5 | month = Mar | year = 2009 | doi = 10.1038/modpathol.2008.198 | PMID = 19136930 }}</ref> however, the details of their definitions are different. | **''Tumour deposits'' conceptually are the samething as the ''in-transit metastases'';<ref name=pmid19136930>{{Cite journal | last1 = Puppa | first1 = G. | last2 = Ueno | first2 = H. | last3 = Kayahara | first3 = M. | last4 = Capelli | first4 = P. | last5 = Canzonieri | first5 = V. | last6 = Colombari | first6 = R. | last7 = Maisonneuve | first7 = P. | last8 = Pelosi | first8 = G. | title = Tumor deposits are encountered in advanced colorectal cancer and other adenocarcinomas: an expanded classification with implications for colorectal cancer staging system including a unifying concept of in-transit metastases. | journal = Mod Pathol | volume = 22 | issue = 3 | pages = 410-5 | month = Mar | year = 2009 | doi = 10.1038/modpathol.2008.198 | PMID = 19136930 }}</ref> however, the details of their definitions are different. | ||
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