Difference between revisions of "In-transit metastasis"

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(get def'n from metastatic disease)
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==Microscopic==
==Microscopic==
Features:
Definition - a separate tumour nodule that is:<ref>URL: [http://www.cancer.gov/dictionary?cdrid=634128 http://www.cancer.gov/dictionary?cdrid=634128]. Accessed on: 28 March 2012.</ref>
*Tumour nodule within a lymphatic with or without extension into the surrounding tissue.
#>2 cm from the primary tumour.
#Arises between the nearest (regional) [[lymph node]]s and the primary tumour.
#*The tumour presumably arises from a lymphatic that drains the tissue in which the primary tumour grew.
 
Notes:
*It is called "in-tranist", as it happens while the tumour is on the way to the regional lymph node.
*If a separate tumour nodule <= 2 cm from the primary tumour, it is known as ''satellitosis''.


DDx:
DDx:

Revision as of 15:07, 11 October 2015

In-transit metastasis is a type of metastatic disease, characterized by tumour nodules growing within lymphatics.[1]

It is relatively common in malignant melanoma.[1] It may be seen in a number of tumours, e.g. squamous cell carinoma,[2][3] ecrrine porocarcinoma[4], Merkel cell carcinoma.[5]

General

  • May be how a tumour (e.g. melanoma[6]) recurs.
  • Poor prognosticator.

Gross

  • Often not apparent.

Microscopic

Definition - a separate tumour nodule that is:[7]

  1. >2 cm from the primary tumour.
  2. Arises between the nearest (regional) lymph nodes and the primary tumour.
    • The tumour presumably arises from a lymphatic that drains the tissue in which the primary tumour grew.

Notes:

  • It is called "in-tranist", as it happens while the tumour is on the way to the regional lymph node.
  • If a separate tumour nodule <= 2 cm from the primary tumour, it is known as satellitosis.

DDx:

See also

References

  1. 1.0 1.1 Fraker, DL. (Jun 2004). "Management of in-transit melanoma of the extremity with isolated limb perfusion.". Curr Treat Options Oncol 5 (3): 173-84. PMID 15115646.
  2. Kocatürk, E.; Ülkümen, PK.; Kızıltaç, U.; Yüksel, T.; Kunter, AS.; Erhan, SŞ.. "In-transit metastasis from primary cutaneous squamous cell carcinoma in a nonimmunosuppressed patient.". J Cutan Med Surg 19 (2): 167-70. doi:10.2310/7750.2014.14047. PMID 25775628.
  3. Altunay, I.; Çerman, AA.; Sakiz, D.; Ates, B. (Aug 2015). "Marjolin's Ulcer Presenting with In-Transit Metastases: A Case Report and Literature Review.". Ann Dermatol 27 (4): 442-5. doi:10.5021/ad.2015.27.4.442. PMID 26273163.
  4. Imafuku, K.; Hata, H.; Kitamura, S.; Iwata, H.; Shimizu, H. (Jul 2015). "In-transit metastasis of advanced eccrine porocarcinoma.". Int J Dermatol. doi:10.1111/ijd.12928. PMID 26234455.
  5. Gunaratne, DA.; Howle, JR.; Veness, MJ. (Mar 2015). "Merkel cell carcinoma: A case of palliative upper limb amputation in a patient with refractory in-transit metastases.". Australas J Dermatol. doi:10.1111/ajd.12291. PMID 25754425.
  6. Grotz, TE.; Mansfield, AS.; Kottschade, LA.; Erickson, LA.; Otley, CC.; Markovic, SN.; Jakub, JW. (Dec 2011). "In-transit melanoma: an individualized approach.". Oncology (Williston Park) 25 (14): 1340-8. PMID 22329185.
  7. URL: http://www.cancer.gov/dictionary?cdrid=634128. Accessed on: 28 March 2012.