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Immunohistochemical staining (view source)
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*TTF-1 ([[thyroid transcription factor-1]]) -- +ve in thyroid gland malignancies. | *TTF-1 ([[thyroid transcription factor-1]]) -- +ve in thyroid gland malignancies. | ||
**Very good for [[breast]] vs. [[lung]].<ref name=pmid18318581>{{cite journal |author=Jagirdar J |title=Application of immunohistochemistry to the diagnosis of primary and metastatic carcinoma to the lung |journal=Arch. Pathol. Lab. Med. |volume=132 |issue=3 |pages=384–96 |year=2008 |month=March |pmid=18318581 |doi= |url=http://journals.allenpress.com/jrnlserv/?request=get-abstract&issn=0003-9985&volume=132&page=384}}</ref> | **Very good for [[breast]] vs. [[lung]].<ref name=pmid18318581>{{cite journal |author=Jagirdar J |title=Application of immunohistochemistry to the diagnosis of primary and metastatic carcinoma to the lung |journal=Arch. Pathol. Lab. Med. |volume=132 |issue=3 |pages=384–96 |year=2008 |month=March |pmid=18318581 |doi= |url=http://journals.allenpress.com/jrnlserv/?request=get-abstract&issn=0003-9985&volume=132&page=384}}</ref> | ||
***Often negative in squamous cell carcinoma of the lung (as with CK7 & CK20), though HMWK is usually positive. | ***Often negative in squamous cell carcinoma of the lung (as with [[CK7]] & [[CK20]]), though HMWK is usually positive. | ||
*Thyroglobulin usu. +ve in the thyroid.<ref>{{Cite journal | last1 = Dralle | first1 = H. | last2 = Böcker | first2 = W. | title = [Thyroglobulin immunohistochemistry: new aspects of pathophysiology and differential diagnosis of benign and malignant goitre (author's transl)]. | journal = Langenbecks Arch Chir | volume = 356 | issue = 3 | pages = 205-12 | month = | year = 1982 | doi = | PMID = 7070163 }}</ref> | *Thyroglobulin usu. +ve in the thyroid.<ref>{{Cite journal | last1 = Dralle | first1 = H. | last2 = Böcker | first2 = W. | title = [Thyroglobulin immunohistochemistry: new aspects of pathophysiology and differential diagnosis of benign and malignant goitre (author's transl)]. | journal = Langenbecks Arch Chir | volume = 356 | issue = 3 | pages = 205-12 | month = | year = 1982 | doi = | PMID = 7070163 }}</ref> | ||
**Negative in classic [[medullary thyroid carcinoma]].<ref name=pmid8454270>{{Cite journal | last1 = de Micco | first1 = C. | last2 = Chapel | first2 = F. | last3 = Dor | first3 = AM. | last4 = Garcia | first4 = S. | last5 = Ruf | first5 = J. | last6 = Carayon | first6 = P. | last7 = Henry | first7 = JF. | last8 = Lebreuil | first8 = G. | title = Thyroglobulin in medullary thyroid carcinoma: immunohistochemical study with polyclonal and monoclonal antibodies. | journal = Hum Pathol | volume = 24 | issue = 3 | pages = 256-62 | month = Mar | year = 1993 | doi = | PMID = 8454270 }}</ref> | **Negative in classic [[medullary thyroid carcinoma]].<ref name=pmid8454270>{{Cite journal | last1 = de Micco | first1 = C. | last2 = Chapel | first2 = F. | last3 = Dor | first3 = AM. | last4 = Garcia | first4 = S. | last5 = Ruf | first5 = J. | last6 = Carayon | first6 = P. | last7 = Henry | first7 = JF. | last8 = Lebreuil | first8 = G. | title = Thyroglobulin in medullary thyroid carcinoma: immunohistochemical study with polyclonal and monoclonal antibodies. | journal = Hum Pathol | volume = 24 | issue = 3 | pages = 256-62 | month = Mar | year = 1993 | doi = | PMID = 8454270 }}</ref> | ||