Immune thrombocytopenic purpura
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Immune thrombocytopenic purpura, abbreviated ITP, is a rare condition.
General
- Uncommon.
- Usually treated with corticosteroids and splenectomy.[1]
Gross
Features:[2]
- Typically ~ 100 grams.
- +/-Prominent white nodules (AKA Malpighian corpuscles) - uncommon.
Microscopic
Features:[2]
- Germinal centres in white pulp (~55% of cases)
- Classically described as "proliferative".
- Neutrophils in the red pulp (~67% of cases).
- Macrophages in the red pulp (~25% of cases). †
Notes:
- Changes not dependent on titre of antiplatelet antibodies.[2]
- † May be a finding associated with treatment.[2]
- The classic changes are proliferation of lymphoid germinal centres and red pulp PMNs.
Images
See also
References
- ↑ Zhang, C.; Liu, HF.; Chen, XH.; Gao, L.; Gao, L.; Liu, Y.; Kong, PY.; Sun, AH. et al. (Mar 2014). "Is splenectomy necessary for immune thrombocytopenic purpura? The role of rituximab in patients with corticosteroid resistance in a single-center experience.". Clin Ther 36 (3): 385-8. doi:10.1016/j.clinthera.2014.01.017. PMID 24594069.
- ↑ 2.0 2.1 2.2 2.3 Hayes MM, Jacobs P, Wood L, Dent DM (September 1985). "Splenic pathology in immune thrombocytopenia". J. Clin. Pathol. 38 (9): 985–8. PMC 499346. PMID 4044880. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC499346/.