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Difference between revisions of "Immune thrombocytopenic purpura"
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Immune thrombocytopenic purpura (view source)
Revision as of 17:19, 7 September 2016
, 17:19, 7 September 2016→General
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| Synonyms = immune thrombocytopenia | | Synonyms = immune thrombocytopenia, idiopathic thrombocytopenic purpura | ||
| Micro = germinal centres in white pulp (~55% of cases), [[neutrophil]]s in the red pulp (~67% of cases), macrophages in the red pulp | | Micro = germinal centres in white pulp (~55% of cases), [[neutrophil]]s in the red pulp (~67% of cases), macrophages in the red pulp | ||
| Subtypes = clinical: primary, secondary | | Subtypes = clinical: primary, secondary | ||
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| IF = | | IF = | ||
| Gross = +/-prominent white nodules (spleen), normal appearance (most common) | | Gross = +/-prominent white nodules (spleen), normal appearance (most common) | ||
| Grossing = | | Grossing = [[splenectomy grossing]] | ||
| Site = systemic - see ''[[spleen]]'' | | Site = systemic - see ''[[spleen]]'' | ||
| Assdx = | | Assdx = | ||
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}} | }} | ||
'''Immune thrombocytopenic purpura''', abbreviated '''ITP''', is a rare condition. | '''Immune thrombocytopenic purpura''', abbreviated '''ITP''', is a rare condition. | ||
It is also known as ''idiopathic thrombocytopenic purpura''.<ref>URL: [https://medlineplus.gov/ency/article/000535.htm https://medlineplus.gov/ency/article/000535.htm]. Accessed on: 7 September 2016.</ref> | |||
==General== | ==General== | ||
*A common non-trauma reason for [[splenectomy]].<ref name=pmid24798604>{{Cite journal | last1 = Jankulovski | first1 = N. | last2 = Antovic | first2 = S. | last3 = Kuzmanovska | first3 = B. | last4 = Mitevski | first4 = A. | title = Splenectomy for haematological disorders. | journal = Pril (Makedon Akad Nauk Umet Odd Med Nauki) | volume = 35 | issue = 1 | pages = 181-7 | month = | year = 2014 | doi = | PMID = 24798604 }}</ref> | |||
Presentation: | Presentation: | ||
*Bleeding - usually.<ref name=pmid23714309>{{cite journal |author=Kistangari G, McCrae KR |title=Immune thrombocytopenia |journal=Hematol. Oncol. Clin. North Am. |volume=27 |issue=3 |pages=495–520 |year=2013 |month=June |pmid=23714309 |doi=10.1016/j.hoc.2013.03.001 |url=}}</ref> | *Bleeding - usually.<ref name=pmid23714309>{{cite journal |author=Kistangari G, McCrae KR |title=Immune thrombocytopenia |journal=Hematol. Oncol. Clin. North Am. |volume=27 |issue=3 |pages=495–520 |year=2013 |month=June |pmid=23714309 |doi=10.1016/j.hoc.2013.03.001 |url=}}</ref> | ||
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***[[Systemic lupus erythematosus]].<ref>{{cite journal |author=Cines DB, Liebman H, Stasi R |title=Pathobiology of secondary immune thrombocytopenia |journal=Semin. Hematol. |volume=46 |issue=1 Suppl 2 |pages=S2–14 |year=2009 |month=January |pmid=19245930 |pmc=2682438 |doi=10.1053/j.seminhematol.2008.12.005 |url=}}</ref> | ***[[Systemic lupus erythematosus]].<ref>{{cite journal |author=Cines DB, Liebman H, Stasi R |title=Pathobiology of secondary immune thrombocytopenia |journal=Semin. Hematol. |volume=46 |issue=1 Suppl 2 |pages=S2–14 |year=2009 |month=January |pmid=19245930 |pmc=2682438 |doi=10.1053/j.seminhematol.2008.12.005 |url=}}</ref> | ||
**Viral. | **Viral. | ||
**Bacterial - possibly [[Helicobacter pylori]].<ref>{{cite journal |author=Kuwana M |title=Helicobacter pylori-associated immune thrombocytopenia: clinical features and pathogenic mechanisms |journal=World J. Gastroenterol. |volume=20 |issue=3 |pages=714–23 |year=2014 |month=January |pmid=24574745 |pmc=3921481 |doi=10.3748/wjg.v20.i3.714 |url=}}</ref> | **Bacterial - possibly [[Helicobacter pylori]].<ref name=pmid24574745>{{cite journal |author=Kuwana M |title=Helicobacter pylori-associated immune thrombocytopenia: clinical features and pathogenic mechanisms |journal=World J. Gastroenterol. |volume=20 |issue=3 |pages=714–23 |year=2014 |month=January |pmid=24574745 |pmc=3921481 |doi=10.3748/wjg.v20.i3.714 |url=}}</ref><ref name=pmid25728540>{{Cite journal | last1 = Frydman | first1 = GH. | last2 = Davis | first2 = N. | last3 = Beck | first3 = PL. | last4 = Fox | first4 = JG. | title = Helicobacter pylori Eradication in Patients with Immune Thrombocytopenic Purpura: A Review and the Role of Biogeography. | journal = Helicobacter | volume = 20 | issue = 4 | pages = 239-51 | month = Aug | year = 2015 | doi = 10.1111/hel.12200 | PMID = 25728540 }}</ref> | ||
==Gross== | ==Gross== | ||
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==Sign out== | ==Sign out== | ||
<pre> | |||
Spleen, Splenetectomy: | |||
- Spleen with prominent red pulp macrophages and expanded germinal | |||
centres, pending hematopathology consult. | |||
</pre> | |||
===Block letters=== | |||
<pre> | <pre> | ||
SPLEEN, SPLENECTOMY: | SPLEEN, SPLENECTOMY: | ||