Difference between revisions of "Immune thrombocytopenic purpura"

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*Changes not dependent on titre of antiplatelet antibodies.<ref name=pmid4044880/>
*Changes not dependent on titre of antiplatelet antibodies.<ref name=pmid4044880/>
*† May be a finding associated with treatment.<ref name=pmid4044880/>
*† May be a finding associated with treatment.<ref name=pmid4044880/>
*The classic changes are ''proliferation of lymphoid germinal centres'' and red pulp [[PMN]]s.
*The classic changes are ''proliferation of lymphoid germinal centres'' and ''red pulp [[PMN]]s''.


===Images===
===Images===

Revision as of 03:35, 6 May 2014

Immune thrombocytopenic purpura, abbreviated ITP, is a rare condition.

General

  • Uncommon.
  • Usually treated with corticosteroids and splenectomy.[1]

Gross

Features:[2]

  • Typically ~ 100 grams.
  • +/-Prominent white nodules (AKA Malpighian corpuscles) - uncommon.

Microscopic

Features:[2]

  • Germinal centres in white pulp (~55% of cases)
    • Classically described as "proliferative".
  • Neutrophils in the red pulp (~67% of cases).
  • Macrophages in the red pulp (~25% of cases). †

Notes:

  • Changes not dependent on titre of antiplatelet antibodies.[2]
  • † May be a finding associated with treatment.[2]
  • The classic changes are proliferation of lymphoid germinal centres and red pulp PMNs.

Images

See also

References

  1. Zhang, C.; Liu, HF.; Chen, XH.; Gao, L.; Gao, L.; Liu, Y.; Kong, PY.; Sun, AH. et al. (Mar 2014). "Is splenectomy necessary for immune thrombocytopenic purpura? The role of rituximab in patients with corticosteroid resistance in a single-center experience.". Clin Ther 36 (3): 385-8. doi:10.1016/j.clinthera.2014.01.017. PMID 24594069.
  2. 2.0 2.1 2.2 2.3 Hayes MM, Jacobs P, Wood L, Dent DM (September 1985). "Splenic pathology in immune thrombocytopenia". J. Clin. Pathol. 38 (9): 985–8. PMC 499346. PMID 4044880. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC499346/.