Difference between revisions of "Immune thrombocytopenic purpura"
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==Microscopic== | ==Microscopic== | ||
Features:<ref name=pmid4044880>{{cite journal |author=Hayes MM, Jacobs P, Wood L, Dent DM |title=Splenic pathology in immune thrombocytopenia |journal=J. Clin. Pathol. |volume=38 |issue=9 |pages=985–8 |year=1985 |month=September |pmid=4044880 |pmc=499346 |doi= |url=}}</ref> | Features:<ref name=pmid4044880>{{cite journal |author=Hayes MM, Jacobs P, Wood L, Dent DM |title=Splenic pathology in immune thrombocytopenia |journal=J. Clin. Pathol. |volume=38 |issue=9 |pages=985–8 |year=1985 |month=September |pmid=4044880 |pmc=499346 |doi= |url=}}</ref> | ||
* | *Germinal centres in white pulp (~55% of cases) | ||
**Classically described as "proliferative". | |||
*Neutrophils in the red pulp (~67% of cases). | *Neutrophils in the red pulp (~67% of cases). | ||
*Macrophages in the red pulp (~25% of cases). † | |||
Notes: | |||
*Changes not dependent on titre of antiplatelet antibodies.<ref name=pmid4044880/> | |||
*† May be a finding associated with treatment.<ref name=pmid4044880/> | |||
*The classic changes are ''proliferation of lymphoid germinal centres'' and red pulp [[PMN]]s. | |||
===Images=== | ===Images=== | ||
Revision as of 03:34, 6 May 2014
Immune thrombocytopenic purpura, abbreviated ITP, is a rare condition.
General
- Uncommon.
- Usually treated with corticosteroids and splenectomy.[1]
Gross
Features:[2]
- Typically ~ 100 grams.
- +/-Prominent white nodules (AKA Malpighian corpuscles) - uncommon.
Microscopic
Features:[2]
- Germinal centres in white pulp (~55% of cases)
- Classically described as "proliferative".
- Neutrophils in the red pulp (~67% of cases).
- Macrophages in the red pulp (~25% of cases). †
Notes:
- Changes not dependent on titre of antiplatelet antibodies.[2]
- † May be a finding associated with treatment.[2]
- The classic changes are proliferation of lymphoid germinal centres and red pulp PMNs.
Images
See also
References
- ↑ Zhang, C.; Liu, HF.; Chen, XH.; Gao, L.; Gao, L.; Liu, Y.; Kong, PY.; Sun, AH. et al. (Mar 2014). "Is splenectomy necessary for immune thrombocytopenic purpura? The role of rituximab in patients with corticosteroid resistance in a single-center experience.". Clin Ther 36 (3): 385-8. doi:10.1016/j.clinthera.2014.01.017. PMID 24594069.
- ↑ 2.0 2.1 2.2 2.3 Hayes MM, Jacobs P, Wood L, Dent DM (September 1985). "Splenic pathology in immune thrombocytopenia". J. Clin. Pathol. 38 (9): 985–8. PMC 499346. PMID 4044880. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC499346/.