Difference between revisions of "Hypersensitivity"

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==Gell & Goombs classification==
==Gell & Goombs classification==
Memory device ''ACID'':<ref>URL: [http://www.saintcyr.com/2001/mnemonic.html http://www.saintcyr.com/2001/mnemonic.html]. Accessed on: 13 November 2011.</ref> Allergy, Cytotoxic-mediated, Immune-complex disease, Delayed hypersensitivity.
 


{|Class="wikitable"
{|Class="wikitable"
! Type (I-IV)
! Type (I-IV)
! Formal name<ref>{{Ref PCPBoD8|110}}</ref>
! Name
! Name
! Example
! Example
! Etiology
! Mediator
! Pathology
|-
|-
| I
| I
| Allergy
| Immediate h.
| Example
| Allergic h.
| Etiology
| [[anaphylaxis]], (atopic) bronchial [[asthma]], allergies
| IgE
| mast cells, inflammation (esp. eosinophils), edema
|-
|-
| II
| II
| Cytotoxic antibody dependent
| Antibody mediated h.
| Example
| Cytotoxic antibody dependent h.
| Etiology
| [[Goodpasture syndrome]]
| antibodies (IgG, IgM)
| (antibody-mediated) phagocytosis & lysis
|-
|-
| III
| III
| Immune complex disease
| Immune complex mediated h.
| Example
| Immune complex mediated h.
| Etiology
| [[systemic lupus erythematosus]]
| antigen-antibody complex
| inflammation, [[vasculitis]] with [[fibrinoid necrosis]]
|-
|-
| IV
| IV
| Cell-mediated h.
| Delayed-type hypersensitivity
| Delayed-type hypersensitivity
| Example
| tuberculosis
| Etiology
| activated T cells
| perivascular inflammation, [[granuloma]]s
|}
|}


Memory device ''ACID'':<ref>URL: [http://www.saintcyr.com/2001/mnemonic.html http://www.saintcyr.com/2001/mnemonic.html]. Accessed on: 13 November 2011.</ref>
*Allergic, Cytotoxic-mediated, Immune-complex disease, Delayed hypersensitivity.
==See also==
==See also==
*[[Hypersensitivity pneumonitis]].
*[[Hypersensitivity pneumonitis]].
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