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'''Hypersensitivity''' is a thingy one may get | '''Hypersensitivity''' is an inappropriate immune system response. It is a thingy one may get quizzed on. | ||
==Gell & Coombs classification== | |||
Gell & Coombs, in the 1960s, came-up with a classification that has endured. | |||
{|Class="wikitable" | {|Class="wikitable" | ||
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|- | |- | ||
| I | | I | ||
| Immediate h. | | '''Immediate h.''' | ||
| Allergic h. | | Allergic h. | ||
| [[anaphylaxis]], (atopic) bronchial [[asthma]], allergies | | [[anaphylaxis]], (atopic) bronchial [[asthma]], allergies | ||
| IgE | | antibodies (IgE) | ||
| mast cells, inflammation (esp. eosinophils), edema | | mast cells, inflammation (esp. eosinophils), edema | ||
|- | |- | ||
| II | | II | ||
| Antibody mediated h. | | '''Antibody mediated h.''' | ||
| Cytotoxic antibody dependent h. | | Cytotoxic antibody dependent h. | ||
| [[Goodpasture syndrome]] | | [[Goodpasture syndrome]],<ref name=pmid384140>{{Cite journal | last1 = Briggs | first1 = WA. | last2 = Johnson | first2 = JP. | last3 = Teichman | first3 = S. | last4 = Yeager | first4 = HC. | last5 = Wilson | first5 = CB. | title = Antiglomerular basement membrane antibody-mediated glomerulonephritis and Goodpasture's syndrome. | journal = Medicine (Baltimore) | volume = 58 | issue = 5 | pages = 348-61 | month = Sep | year = 1979 | doi = | PMID = 384140 }}</ref> [[Graves disease]] | ||
| antibodies (IgG, IgM) | | antibodies (IgG, IgM) | ||
| (antibody-mediated) phagocytosis & lysis | | (antibody-mediated) phagocytosis & lysis | ||
|- | |- | ||
| III | | III | ||
| '''Immune complex mediated h.''' | |||
| Immune complex mediated h. | | Immune complex mediated h. | ||
| [[systemic lupus erythematosus]], [[hypersensitivity pneumonitis]],<ref name=pmid8279154>{{Cite journal | last1 = Kaltreider | first1 = HB. | title = Hypersensitivity pneumonitis. | journal = West J Med | volume = 159 | issue = 5 | pages = 570-8 | month = Nov | year = 1993 | doi = | PMID = 8279154 | url = http://www.ncbi.nlm.nih.gov/pmc/articles/pmid/8279154/?tool=pubmed }}</ref> [[rheumatoid arthritis]] | |||
| [[systemic lupus erythematosus]] | |||
| antigen-antibody complex | | antigen-antibody complex | ||
| inflammation, [[vasculitis]] with [[fibrinoid necrosis]] | | inflammation, [[vasculitis]] with [[fibrinoid necrosis]] | ||
|- | |- | ||
| IV | | IV | ||
| Cell-mediated h. | | '''Cell-mediated h.''' | ||
| Delayed-type hypersensitivity | | Delayed-type hypersensitivity | ||
| tuberculosis | | [[tuberculosis]], [[contact dermatitis]], chronic transplant rejection, [[inflammatory bowel disease]] | ||
| activated T cells | | activated T cells | ||
| perivascular inflammation, [[granuloma]]s | | perivascular inflammation, [[granuloma]]s | ||
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Memory device ''ACID'':<ref>URL: [http://www.saintcyr.com/2001/mnemonic.html http://www.saintcyr.com/2001/mnemonic.html]. Accessed on: 13 November 2011.</ref> | Memory device ''ACID'':<ref>URL: [http://www.saintcyr.com/2001/mnemonic.html http://www.saintcyr.com/2001/mnemonic.html]. Accessed on: 13 November 2011.</ref> | ||
*Allergic, Cytotoxic-mediated, Immune-complex disease, Delayed hypersensitivity. | *Allergic, Cytotoxic-mediated, Immune-complex disease, Delayed hypersensitivity. | ||
==See also== | ==See also== | ||
*[[Hypersensitivity pneumonitis]]. | *[[Hypersensitivity pneumonitis]]. | ||
*[[Common variable immunodeficiency]]. | |||
==References== | ==References== | ||
{{Reflist| | {{Reflist|2}} | ||
[[Category:Stuff]] | [[Category:Stuff]] |
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