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Difference between revisions of "Hyperplastic polyp"
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| Caption = Hyperplastic polyp. [[H&E stain]]. | | Caption = Hyperplastic polyp. [[H&E stain]]. | ||
| Micro = serrated architecture at the surface without glandular abnormalities | | Micro = serrated architecture at the surface without glandular abnormalities | ||
| Subtypes = microvesicular serrated polyps (MVSPs), goblet cell serrated polyps (GCSPs) | | Subtypes = microvesicular serrated polyps (MVSPs), goblet cell serrated polyps (GCSPs) | ||
| LMDDx = [[sessile serrated adenoma]], [[normal colon]], other [[gastrointestinal polyps]] | | LMDDx = [[sessile serrated adenoma]], [[normal colon]], [[hyperplastic polyp with perineuromatous stroma]], other [[gastrointestinal polyps]] | ||
| Stains = | | Stains = | ||
| IHC = | | IHC = [[Chromogranin A]] +ve (increased scattered Chromogranin A-positive cells in relation to normal mucosa) | ||
| EM = | | EM = | ||
| Molecular = | | Molecular = | ||
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**No nuclear atypia; glands ''d''arker staining ''d''eep... ''l''ighter staining ''l''uminal. | **No nuclear atypia; glands ''d''arker staining ''d''eep... ''l''ighter staining ''l''uminal. | ||
**In the colon goblet cells should be present (as is usual). | **In the colon goblet cells should be present (as is usual). | ||
*Inflammation -- cryptitis or even crypt abscesses -- is considered to arise due to trauma.{{fact}} | *Inflammation -- [[cryptitis]] or even crypt abscesses -- is considered to arise due to trauma.{{fact}} | ||
**It is usually ''not'' reported. | **It is usually ''not'' reported. | ||
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*[[Sessile serrated adenoma]]. | *[[Sessile serrated adenoma]]. | ||
*[[Normal colon]]. | *[[Normal colon]]. | ||
*[[Colorectal xanthomatous polyp|Xanthomatous polyp]] with hyperplastic features.<ref name=pmid14961968>{{Cite journal | last1 = Nakasono | first1 = M. | last2 = Hirokawa | first2 = M. | last3 = Muguruma | first3 = N. | last4 = Okahisa | first4 = T. | last5 = Okamura | first5 = S. | last6 = Ito | first6 = S. | last7 = Miyamoto | first7 = H. | last8 = Wada | first8 = S. | last9 = Fukuda | first9 = T. | title = Colorectal xanthomas with polypoid lesion: report of 25 cases. | journal = APMIS | volume = 112 | issue = 1 | pages = 3-10 | month = Jan | year = 2004 | doi = | PMID = 14961968 }}</ref> | |||
*[[Hyperplastic polyp with perineuromatous stroma]]. | |||
===Images=== | ===Images=== | ||
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Image: Hyperplastic polyp -- intermed mag.jpg | HP - intermed. mag. (WC) | Image: Hyperplastic polyp -- intermed mag.jpg | HP - intermed. mag. (WC) | ||
Image: Hyperplastic polyp -- alt - intermed mag.jpg | HP - intermed. mag. (WC) | Image: Hyperplastic polyp -- alt - intermed mag.jpg | HP - intermed. mag. (WC) | ||
Image: Hyperplastic polyp -- high mag.jpg | HP - high mag. (WC) | |||
</gallery> | </gallery> | ||
www: | www: | ||
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| Goblet cell | | Goblet cell | ||
| superficial goblet cells, serration at <br>the surface | | superficial goblet cells, serration at <br>the surface | ||
| KRAS | | [[KRAS mutation|KRAS]] | ||
| unknown; probably benign | | unknown; probably benign | ||
|} | |} | ||
Notes: | Notes: | ||
*CIMP = CpG island methylation phenotype. | *CIMP = CpG island methylation phenotype. | ||
==IHC== | |||
*[[Chromogranin A]] increased scattered Chromogranin A-positive cells (in relation to normal colorectal mucosa). | |||
**[[Sessile serrated adenoma]] is completely negative for [[Chromogranin A]]. | |||
==Sign out== | ==Sign out== | ||
<pre> | <pre> | ||
POLYP, RECTUM, | POLYP, RECTUM, POLYPECTOMY: | ||
- HYPERPLASTIC POLYP. | - HYPERPLASTIC POLYP. | ||
</pre> | </pre> | ||
<pre> | <pre> | ||
POLYP, SIGMOID COLON, | POLYP, SIGMOID COLON, POLYPECTOMY: | ||
- HYPERPLASTIC POLYP. | - HYPERPLASTIC POLYP. | ||
</pre> | </pre> | ||
<pre> | <pre> | ||
POLYP, DESCENDING COLON, | POLYP, DESCENDING COLON, POLYPECTOMY: | ||
- HYPERPLASTIC POLYP. | - HYPERPLASTIC POLYP. | ||
</pre> | </pre> | ||
<pre> | <pre> | ||
POLYP, TRANSVERSE COLON, | POLYP, TRANSVERSE COLON, POLYPECTOMY: | ||
- HYPERPLASTIC POLYP. | - HYPERPLASTIC POLYP. | ||
</pre> | </pre> | ||
<pre> | <pre> | ||
COLONIC POLYP, 35 CM, | COLONIC POLYP, 35 CM, POLYPECTOMY: | ||
- HYPERPLASTIC POLYP. | - HYPERPLASTIC POLYP. | ||
</pre> | </pre> | ||
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====Numerous hyperplastic polyps==== | ====Numerous hyperplastic polyps==== | ||
<pre> | <pre> | ||
COLONIC POLYP(S), | COLONIC POLYP(S), POLYPECTOMY: | ||
- HYPERPLASTIC POLYP, SEE COMMENT. | - HYPERPLASTIC POLYP, SEE COMMENT. | ||
| Line 166: | Line 172: | ||
pathologic change. The second fragment has the changes of a hyperplastic polyp | pathologic change. The second fragment has the changes of a hyperplastic polyp | ||
(superficial serrations, no serrations in the crypt base, no crypt base dilation). | (superficial serrations, no serrations in the crypt base, no crypt base dilation). | ||
====Minimal crypt base dilation==== | |||
The sections show colonic-type mucosa with superficial serrations. Rare serrations are seen | |||
focally near the crypt base. Rare mild crypt base dilation is seen. No hockey stick-shaped | |||
glands are identified. No crypt branching is seen. No dysplasia is present. | |||
==See also== | ==See also== | ||
*[[Gastrointestinal tract polyps]]. | *[[Gastrointestinal tract polyps]]. | ||
*[[Gastrointestinal pathology]]. | *[[Gastrointestinal pathology]]. | ||
*[[Hyperplastic polyp with perineuromatous stroma]]. | |||
==References== | ==References== | ||