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Difference between revisions of "Hyalinizing clear cell carcinoma"
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Hyalinizing clear cell carcinoma (view source)
Revision as of 16:00, 13 March 2016
, 16:00, 13 March 2016→Microscopic
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| Micro = cells with abundant clear cytoplasm in cords, trabeculae or clusters; minimal [[nuclear pleomorphism]]; hyalinized stroma | | Micro = cells with abundant clear cytoplasm in cords, trabeculae or clusters; minimal [[nuclear pleomorphism]]; hyalinized stroma | ||
| Subtypes = | | Subtypes = | ||
| LMDDx = | | LMDDx = [[mucoepidermoid carcinoma]] (clear cell variant), [[acinic cell carcinoma]] (clear cell variant), metastatic [[clear cell renal cell carcinoma]], [[epithelial-myoepithelial carcinoma]], other [[clear cell tumours]] | ||
| Stains = PAS +ve | | Stains = PAS +ve | ||
| IHC = AE1/AE3 +ve, EMA +ve. | | IHC = AE1/AE3 +ve, EMA +ve. | ||
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| Gross = | | Gross = | ||
| Grossing = | | Grossing = | ||
| Site = usu. palate or tongue | | Site = usu. palate or [[tongue]] | ||
| Assdx = | | Assdx = | ||
| Syndromes = | | Syndromes = | ||
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*Clear cytoplasm due to glycogen.<ref name=pmid7506496>{{Cite journal | last1 = Milchgrub | first1 = S. | last2 = Gnepp | first2 = DR. | last3 = Vuitch | first3 = F. | last4 = Delgado | first4 = R. | last5 = Albores-Saavedra | first5 = J. | title = Hyalinizing clear cell carcinoma of salivary gland. | journal = Am J Surg Pathol | volume = 18 | issue = 1 | pages = 74-82 | month = Jan | year = 1994 | doi = | PMID = 7506496 }}</ref> | *Clear cytoplasm due to glycogen.<ref name=pmid7506496>{{Cite journal | last1 = Milchgrub | first1 = S. | last2 = Gnepp | first2 = DR. | last3 = Vuitch | first3 = F. | last4 = Delgado | first4 = R. | last5 = Albores-Saavedra | first5 = J. | title = Hyalinizing clear cell carcinoma of salivary gland. | journal = Am J Surg Pathol | volume = 18 | issue = 1 | pages = 74-82 | month = Jan | year = 1994 | doi = | PMID = 7506496 }}</ref> | ||
*Low mitotic rate. | *Low mitotic rate. | ||
*Should ''not'' have epidermoid or mucinous differentiation - seen in clear cell variant of mucoepidermoid carcinoma. | |||
DDx: | DDx: | ||
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**Classically have hemorrhage & [[necrosis]]. | **Classically have hemorrhage & [[necrosis]]. | ||
*[[Epithelial-myoepithelial carcinoma]]. | *[[Epithelial-myoepithelial carcinoma]]. | ||
*Other [[clear cell tumours]]. | |||
===Images=== | ===Images=== | ||
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*[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2811632/figure/Fig2/ HCCC (nlm.nih.gov)]. | *[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2811632/figure/Fig2/ HCCC (nlm.nih.gov)]. | ||
*[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2811632/figure/Fig5/ HCCC (nlm.nih.gov)].<ref name=pmid20596970/> | *[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2811632/figure/Fig5/ HCCC (nlm.nih.gov)].<ref name=pmid20596970/> | ||
==Stains== | ==Stains== | ||
*PAS +ve. | *PAS +ve. | ||