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Difference between revisions of "Human papillomavirus-associated head and neck squamous cell carcinoma"
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Human papillomavirus-associated head and neck squamous cell carcinoma (view source)
Revision as of 16:41, 22 December 2020
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| Assdx = | | Assdx = | ||
| Syndromes = | | Syndromes = | ||
| Clinicalhx = typically male | | Clinicalhx = typically male, younger than typical H&N SCC, +/-homosexual practices | ||
| Signs = | | Signs = | ||
| Symptoms = | | Symptoms = | ||
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*Tumours associated with high risk HPV, typically [[HPV]] 16.<ref name=pmid22001331 >{{Cite journal | last1 = Wang | first1 = XI. | last2 = Thomas | first2 = J. | last3 = Zhang | first3 = S. | title = Changing trends in human papillomavirus-associated head and neck squamous cell carcinoma. | journal = Ann Diagn Pathol | volume = 16 | issue = 1 | pages = 7-12 | month = Jan | year = 2012 | doi = 10.1016/j.anndiagpath.2011.07.003 | PMID = 22001331 }}</ref> | *Tumours associated with high risk HPV, typically [[HPV]] 16.<ref name=pmid22001331 >{{Cite journal | last1 = Wang | first1 = XI. | last2 = Thomas | first2 = J. | last3 = Zhang | first3 = S. | title = Changing trends in human papillomavirus-associated head and neck squamous cell carcinoma. | journal = Ann Diagn Pathol | volume = 16 | issue = 1 | pages = 7-12 | month = Jan | year = 2012 | doi = 10.1016/j.anndiagpath.2011.07.003 | PMID = 22001331 }}</ref> | ||
**Thought to be different that tumours driven by [[alcohol]] and [[smoking|tobacco]] use.<ref name=pmid21769577>{{Cite journal | last1 = Wittekindt | first1 = C. | last2 = Wagner | first2 = S. | last3 = Klussmann | first3 = JP. | title = [HPV-associated head and neck cancer. The basics of molecular and translational research]. | journal = HNO | volume = 59 | issue = 9 | pages = 885-92 | month = Sep | year = 2011 | doi = 10.1007/s00106-011-2357-1 | PMID = 21769577 }}</ref> | **Thought to be different that tumours driven by [[alcohol]] and [[smoking|tobacco]] use.<ref name=pmid21769577>{{Cite journal | last1 = Wittekindt | first1 = C. | last2 = Wagner | first2 = S. | last3 = Klussmann | first3 = JP. | title = [HPV-associated head and neck cancer. The basics of molecular and translational research]. | journal = HNO | volume = 59 | issue = 9 | pages = 885-92 | month = Sep | year = 2011 | doi = 10.1007/s00106-011-2357-1 | PMID = 21769577 }}</ref> | ||
***Patients tend to be male and slightly younger - risk thought to be due to sexual practices.<ref name=pmid22046680>{{Cite journal | last1 = Vourexakis | first1 = Z. | last2 = Dulguerov | first2 = P. | title = [HPV associated head and neck cancers]. | journal = Rev Med Suisse | volume = 7 | issue = 311 | pages = 1919-22 | month = Oct | year = 2011 | doi = | PMID = 22046680 }}</ref> | ***Patients tend to be male (male:female = 5:1<ref name=pmid26483987>{{Cite journal | last1 = Ajila | first1 = V. | last2 = Shetty | first2 = H. | last3 = Babu | first3 = S. | last4 = Shetty | first4 = V. | last5 = Hegde | first5 = S. | title = Human Papilloma Virus Associated Squamous Cell Carcinoma of the Head and Neck. | journal = J Sex Transm Dis | volume = 2015 | issue = | pages = 791024 | month = | year = 2015 | doi = 10.1155/2015/791024 | PMID = 26483987 }}</ref>) and slightly younger (~4-10 years younger than typical H&N SCC<ref name=pmid24134947>{{Cite journal | last1 = Benson | first1 = E. | last2 = Li | first2 = R. | last3 = Eisele | first3 = D. | last4 = Fakhry | first4 = C. | title = The clinical impact of HPV tumor status upon head and neck squamous cell carcinomas. | journal = Oral Oncol | volume = 50 | issue = 6 | pages = 565-74 | month = Jun | year = 2014 | doi = 10.1016/j.oraloncology.2013.09.008 | PMID = 24134947 }}</ref>) - risk thought to be due to sexual practices.<ref name=pmid22046680>{{Cite journal | last1 = Vourexakis | first1 = Z. | last2 = Dulguerov | first2 = P. | title = [HPV associated head and neck cancers]. | journal = Rev Med Suisse | volume = 7 | issue = 311 | pages = 1919-22 | month = Oct | year = 2011 | doi = | PMID = 22046680 }}</ref> | ||
*Lesions more radiosensitive and usually have a better prognosis.<ref name=pmid22001331/> | *Lesions more radiosensitive and usually have a better prognosis.<ref name=pmid22001331/> | ||
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===Images=== | ===Images=== | ||
====Case 1==== | |||
<gallery> | <gallery> | ||
Image: Squamous cell carcinoma - p16 positive -- very low mag.jpg | SCC p16 positive - very low mag. | Image: Squamous cell carcinoma - p16 positive -- very low mag.jpg | SCC p16 positive - very low mag. | ||
| Line 67: | Line 68: | ||
Image: Squamous cell carcinoma - p16 positive -- very high mag.jpg | SCC p16 positive - very high mag. | Image: Squamous cell carcinoma - p16 positive -- very high mag.jpg | SCC p16 positive - very high mag. | ||
</gallery> | </gallery> | ||
www | ====Case 2==== | ||
<gallery> | |||
Image: Consistent with HPV-associated SCC in muscle -- intermed mag.jpg | c/w HPV-SCC - intermed. mag. | |||
Image: Consistent with HPV-associated SCC in muscle -- high mag.jpg | c/w HPV-SCC - high mag. | |||
Image: Consistent with HPV-associated SCC - p16 -- high mag.jpg | c/w HPV-SCC - [[p16]] - high mag. | |||
Image: Consistent with HPV-associated SCC - p40 -- high mag.jpg | c/w HPV-SCC - [[p40]] - high mag. | |||
Image: Consistent with HPV-associated SCC -- low mag.jpg | c/w HPV-SCC - low mag. | |||
Image: Consistent with HPV-associated SCC -- intermed mag.jpg | c/w HPV-SCC - intermed. mag. | |||
Image: Consistent with HPV-associated SCC - alt -- intermed mag.jpg | c/w HPV-SCC - intermed. mag. | |||
Image: Consistent with HPV-associated SCC -- high mag.jpg | c/w HPV-SCC - high mag. | |||
</gallery> | |||
====www==== | |||
*[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2811624/figure/Fig1/ HPV NK SCC (nih.gov)]. | *[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2811624/figure/Fig1/ HPV NK SCC (nih.gov)]. | ||
==IHC== | ==IHC== | ||
*p16 +ve | *p16 +ve<ref name=pmid21752613>{{Cite journal | last1 = Heath | first1 = S. | last2 = Willis | first2 = V. | last3 = Allan | first3 = K. | last4 = Purdie | first4 = K. | last5 = Harwood | first5 = C. | last6 = Shields | first6 = P. | last7 = Simcock | first7 = R. | last8 = Williams | first8 = T. | last9 = Gilbert | first9 = DC. | title = Clinically significant human papilloma virus in squamous cell carcinoma of the head and neck in UK practice. | journal = Clin Oncol (R Coll Radiol) | volume = 24 | issue = 1 | pages = e18-23 | month = Feb | year = 2012 | doi = 10.1016/j.clon.2011.05.007 | PMID = 21752613 }}</ref> - should be >70% of cells, strong, nuclear and cytoplasmic staining. | ||
*EBV -ve. | *EBV -ve. | ||
*CK5/6 +ve. | *CK5/6 +ve. | ||
*p63 +ve. | *p63 +ve. | ||
A panel: | |||
*p16, CK5/6, CK34betaE12, CD56, synaptophysin, LCA, Ki-67. | |||
==Molecular== | ==Molecular== | ||
*EBER -ve. | *[[EBER]] -ve. | ||
**Positive in [[nasopharyngeal carcinoma]]. | |||
==Sign out== | ==Sign out== | ||