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Difference between revisions of "Human papillomavirus-associated head and neck squamous cell carcinoma"
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Human papillomavirus-associated head and neck squamous cell carcinoma (view source)
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'''Human papillomavirus-associated head and neck squamous cell carcinoma''', abbreviated '''HPV-associated SCC''', is a type of [[head and neck squamous cell carcinoma]]. | |||
It has a unique epidemiology, when compared to conventional head and neck [[squamous cell carcinoma]]. | |||
==General== | |||
*Tumours associated with high risk HPV, typically [[HPV]] 16.<ref name=pmid22001331 >{{Cite journal | last1 = Wang | first1 = XI. | last2 = Thomas | first2 = J. | last3 = Zhang | first3 = S. | title = Changing trends in human papillomavirus-associated head and neck squamous cell carcinoma. | journal = Ann Diagn Pathol | volume = 16 | issue = 1 | pages = 7-12 | month = Jan | year = 2012 | doi = 10.1016/j.anndiagpath.2011.07.003 | PMID = 22001331 }}</ref> | |||
**Thought to be different that tumours driven by [[alcohol]] and [[smoking|tobacco]] use.<ref name=pmid21769577>{{Cite journal | last1 = Wittekindt | first1 = C. | last2 = Wagner | first2 = S. | last3 = Klussmann | first3 = JP. | title = [HPV-associated head and neck cancer. The basics of molecular and translational research]. | journal = HNO | volume = 59 | issue = 9 | pages = 885-92 | month = Sep | year = 2011 | doi = 10.1007/s00106-011-2357-1 | PMID = 21769577 }}</ref> | |||
***Patients tend to be male and slightly younger - risk thought to be due to sexual practices.<ref name=pmid22046680>{{Cite journal | last1 = Vourexakis | first1 = Z. | last2 = Dulguerov | first2 = P. | title = [HPV associated head and neck cancers]. | journal = Rev Med Suisse | volume = 7 | issue = 311 | pages = 1919-22 | month = Oct | year = 2011 | doi = | PMID = 22046680 }}</ref> | |||
*Lesions more radiosensitive and usually have a better prognosis.<ref name=pmid22001331/> | |||
==Gross== | |||
Classic locations: | |||
*Tonsil and base of tongue<ref name=pmid21752613/> (palatine tonsil, lingual tonsil, oropharynx). | |||
Note: | |||
*Memory device: | |||
**Where the tip of the [[penis]] goes when someone is ''deep throating''. | |||
==Microscopic== | |||
Features:<ref name=pmid20596971>{{Cite journal | last1 = Chernock | first1 = RD. | last2 = El-Mofty | first2 = SK. | last3 = Thorstad | first3 = WL. | last4 = Parvin | first4 = CA. | last5 = Lewis | first5 = JS. | title = HPV-related nonkeratinizing squamous cell carcinoma of the oropharynx: utility of microscopic features in predicting patient outcome. | journal = Head Neck Pathol | volume = 3 | issue = 3 | pages = 186-94 | month = Sep | year = 2009 | doi = 10.1007/s12105-009-0126-1 | PMID = 20596971 | PMC = 2811624 | URL = http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2811624/?tool=pubmed }}</ref> | |||
*Typically non-keratinizing squamous cell carcinoma. | |||
DDx: | |||
*HPV-negative squamous cell carcinoma - see ''[[squamous cell carcinoma of the head and neck]]''. | |||
*[[Nasopharyngeal carcinoma]]. | |||
Images: | |||
*[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2811624/figure/Fig1/ HPV NK SCC (nih.gov)]. | |||
==IHC== | |||
*p16 +ve.<ref name=pmid21752613>{{Cite journal | last1 = Heath | first1 = S. | last2 = Willis | first2 = V. | last3 = Allan | first3 = K. | last4 = Purdie | first4 = K. | last5 = Harwood | first5 = C. | last6 = Shields | first6 = P. | last7 = Simcock | first7 = R. | last8 = Williams | first8 = T. | last9 = Gilbert | first9 = DC. | title = Clinically significant human papilloma virus in squamous cell carcinoma of the head and neck in UK practice. | journal = Clin Oncol (R Coll Radiol) | volume = 24 | issue = 1 | pages = e18-23 | month = Feb | year = 2012 | doi = 10.1016/j.clon.2011.05.007 | PMID = 21752613 }}</ref> | |||
*EBER -ve. | |||
==See also== | |||
*[[Head and neck pathology]]. | |||
*[[Squamous cell carcinoma]]. | |||
*[[Nasopharyngeal carcinoma]]. | |||
*[[Squamous cell carcinoma of the head and neck]]. | |||
==References== | |||
{{Reflist|2}} | |||
[[Category:Diagnosis]] | [[Category:Diagnosis]] | ||
[[Category:Head and neck pathology]] | |||