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Difference between revisions of "Hodgkin lymphoma"
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B-cell lymphoma, unclassifiable, with features intermediate between diffuse large B-cell lymphoma and classical Hodgkin lymphoma, nodular lymphocyte-predominant Hodgkin lymphoma | B-cell lymphoma, unclassifiable, with features intermediate between diffuse large B-cell lymphoma and classical Hodgkin lymphoma, nodular lymphocyte-predominant Hodgkin lymphoma | ||
| Stains = | | Stains = | ||
| IHC = CD30 Reed-Sternberg cells (RSCs) +ve ~98%, CD15 Reed-Sternberg cells +ve ~80% (also stains neutrophils), CD45 | | IHC = CD30 Reed-Sternberg cells (RSCs) +ve ~98%, CD15 Reed-Sternberg cells +ve ~80% (also stains neutrophils), CD45 ''often negative'' in RSCs, CD20 -ve/+ve, PAX5 +ve | ||
| EM = | | EM = | ||
| Molecular = | | Molecular = | ||
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| Width = | | Width = | ||
| Caption = Popcorn cell in nodular lymphocyte-predominant Hodgkin lymphoma | | Caption = Popcorn cell in nodular lymphocyte-predominant Hodgkin lymphoma | ||
| Micro = | | Micro = Popcorn cells (relatively) small (compared to classic RSCs) - have lobulated nucleus (key feature), small nucleoli; subtle nodularity at low power | ||
| Subtypes = none | | Subtypes = none | ||
| LMDDx = [[diffuse large B cell lymphoma]] (esp. ''T-cell/histiocytic-rich LBCL''), [[anaplastic large cell lymphoma]], | | LMDDx = [[diffuse large B cell lymphoma]] (esp. ''T-cell/histiocytic-rich LBCL''), [[anaplastic large cell lymphoma]], | ||