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Difference between revisions of "Hodgkin lymphoma"
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+ICH
(tweaak, +infoboxes) |
(+ICH) |
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| Width = | | Width = | ||
| Caption = HL mixed cellularity - cytology. | | Caption = HL mixed cellularity - cytology. | ||
| Micro = Reed-Sternberg cell | | Micro = Reed-Sternberg cell (large binucleated cell (>= 45 micrometres), +/-multinucleated, +/-horseshoe-like shape,[[macronucleolus]] - approximately the size of a RBC (~8 micrometers)), well-defined cell border, abundant cytoplasm. | ||
| Subtypes = nodular sclerosis CHL, mixed cellularity CHL, lymphocyte-rich CHL, lymphocyte-depleted CHL | | Subtypes = nodular sclerosis CHL, mixed cellularity CHL, lymphocyte-rich CHL, lymphocyte-depleted CHL | ||
| LMDDx = | | LMDDx = [[diffuse large B cell lymphoma]] (esp. ''T-cell/histiocytic-rich LBCL''), [[anaplastic large cell lymphoma]], | ||
B-cell lymphoma, unclassifiable, with features intermediate between diffuse large B-cell lymphoma and classical Hodgkin lymphoma, nodular lymphocyte-predominant Hodgkin lymphoma | |||
| Stains = | | Stains = | ||
| IHC = | | IHC = CD30 Reed-Sternberg cells (RSCs) +ve ~98%, CD15 Reed-Sternberg cells +ve ~80% (also stains neutrophils), CD45 '''often negative''' in RSCs, CD20 -ve/+ve, PAX5 +ve | ||
| EM = | | EM = | ||
| Molecular = | | Molecular = | ||
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| Gross = | | Gross = | ||
| Grossing = | | Grossing = | ||
| Site = | | Site = usu. [[lymph node]] - classically in the neck | ||
| Assdx = | | Assdx = | ||
| Syndromes = | | Syndromes = | ||
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| Micro = | | Micro = | ||
| Subtypes = none | | Subtypes = none | ||
| LMDDx = | | LMDDx = [[diffuse large B cell lymphoma]] (esp. ''T-cell/histiocytic-rich LBCL''), [[anaplastic large cell lymphoma]], | ||
B-cell lymphoma, unclassifiable, with features intermediate between diffuse large B-cell lymphoma and classical Hodgkin lymphoma, classical Hodgkin lymphoma | |||
| Stains = | | Stains = | ||
| IHC = | | IHC = LCA (CD45) +ve, CD20 +ve, CD10 +ve, Bcl-6 +ve, EMA +ve, CD30 -ve, CD15 -ve | ||
| EM = | | EM = | ||
| Molecular = | | Molecular = | ||
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| Gross = | | Gross = | ||
| Grossing = | | Grossing = | ||
| Site = | | Site = usu. [[lymph node]] | ||
| Assdx = | | Assdx = | ||
| Syndromes = | | Syndromes = | ||