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Difference between revisions of "Hodgkin lymphoma"
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{{ Infobox diagnosis | |||
| Name = Classical Hodgkin lymphoma | |||
| Image = Hodgkin_lymphoma_cytology_large.jpg | |||
| Width = | |||
| Caption = HL mixed cellularity - cytology. | |||
| Micro = Reed-Sternberg cell | |||
| Subtypes = nodular sclerosis CHL, mixed cellularity CHL, lymphocyte-rich CHL, lymphocyte-depleted CHL | |||
| LMDDx = | |||
| Stains = | |||
| IHC = | |||
| EM = | |||
| Molecular = | |||
| IF = | |||
| Gross = | |||
| Grossing = | |||
| Site = | |||
| Assdx = | |||
| Syndromes = | |||
| Clinicalhx = | |||
| Signs = | |||
| Symptoms = | |||
| Prevalence = common | |||
| Bloodwork = | |||
| Rads = | |||
| Endoscopy = | |||
| Prognosis = | |||
| Other = | |||
| ClinDDx = | |||
}} | |||
{{ Infobox diagnosis | |||
| Name = Nodular lymphocyte-predominant Hodgkin lymphoma | |||
| Image = Popcorn_cell_in_nodular_lymphocyte_predominant_Hodgkin_lymphoma_-_very_high_mag_cropped.jpg | |||
| Width = | |||
| Caption = Popcorn cell in nodular lymphocyte-predominant Hodgkin lymphoma | |||
| Micro = | |||
| Subtypes = none | |||
| LMDDx = | |||
| Stains = | |||
| IHC = | |||
| EM = | |||
| Molecular = | |||
| IF = | |||
| Gross = | |||
| Grossing = | |||
| Site = | |||
| Assdx = | |||
| Syndromes = | |||
| Clinicalhx = | |||
| Signs = | |||
| Symptoms = | |||
| Prevalence = uncommon | |||
| Bloodwork = | |||
| Rads = | |||
| Endoscopy = | |||
| Prognosis = | |||
| Other = | |||
| ClinDDx = | |||
}} | |||
'''Hodgkin [[lymphoma]]''', abbreviated '''HL''', is a [[malignancy]] that often afflicts people in the prime of their life. Fortunately, it usually has a good prognosis. | '''Hodgkin [[lymphoma]]''', abbreviated '''HL''', is a [[malignancy]] that often afflicts people in the prime of their life. Fortunately, it usually has a good prognosis. | ||
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==Microscopic== | ==Microscopic== | ||
By definition, HL has Reed-Sternberg cells (RSCs). | By definition, HL has ''Reed-Sternberg cells'' (RSCs) or ''Popcorn cells''. | ||
===Classical HL=== | ===Classical HL=== | ||
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*Large mononuclear cells are common (so called "mononuclear RSCs") but not diagnostic. | *Large mononuclear cells are common (so called "mononuclear RSCs") but not diagnostic. | ||
Images (classic HL) | ====Images (classic HL)==== | ||
<gallery> | |||
Image:Hodgkin_lymphoma_cytology_large.jpg | HL mixed cellularity - cytology. (WC) | |||
Image:Hodgkin_lymphoma_cytology_small.jpg | HL mixed cellularity - cytology. (WC) | |||
Image:Hodgkin_lymphoma_%281%29_mixed_cellulary_type.jpg | HL mixed cellularity. (WC) | |||
</gallery> | |||
====Subtypes of classic HL==== | ====Subtypes of classic HL==== | ||
There are four CHL subtypes:<ref name=Ref_WMSP567/> | There are four CHL subtypes:<ref name=Ref_WMSP567/> | ||
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*Subtle nodularity at low power (2.5x or 5x objective). | *Subtle nodularity at low power (2.5x or 5x objective). | ||
Images (NLPHL): | ====Images (NLPHL)==== | ||
www: | |||
*[http://webpathology.com/image.asp?case=388&n=16 Popcorn cell (webpathology.com)]. | *[http://webpathology.com/image.asp?case=388&n=16 Popcorn cell (webpathology.com)]. | ||
<gallery> | |||
Image:Popcorn_cell_in_nodular_lymphocyte_predominant_Hodgkin_lymphoma_-_very_high_mag_cropped.jpg | Popcorn cell. (WC) | |||
</gallery> | |||
===DDx both CHL & NLPHL=== | ===DDx both CHL & NLPHL=== | ||
*CHL/NLPHL. | *CHL/NLPHL. | ||