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Difference between revisions of "Hodgkin lymphoma"
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*Classical HL (CHL) - ~95% of HL. | *Classical HL (CHL) - ~95% of HL. | ||
*Nodular lymphocyte-predominant HL (NLPHL) - ~5% of HL. | *Nodular lymphocyte-predominant HL (NLPHL) - ~5% of HL. | ||
===CHL=== | |||
*See ''microscopic'' for subtypes. | |||
===NLPHL=== | |||
*AKA ''lympho-histiocytic variant''. | |||
*Abbreviated ''NLPHL''. | |||
*Different IHC and morphologic appearance than classic HL. | |||
==Microscopic== | ==Microscopic== | ||
By definition, HL has Reed-Sternberg cells (RSCs). | By definition, HL has Reed-Sternberg cells (RSCs). | ||
===Classical HL=== | |||
Features (classic HL): | Features (classic HL): | ||
*Reed-Sternberg cell. | *Reed-Sternberg cell. | ||
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*[http://en.wikipedia.org/wiki/File:Hodgkin_lymphoma_%281%29_mixed_cellulary_type.jpg HL mixed cellularity (WC)]. | *[http://en.wikipedia.org/wiki/File:Hodgkin_lymphoma_%281%29_mixed_cellulary_type.jpg HL mixed cellularity (WC)]. | ||
====Subtypes==== | |||
== | |||
There are four CHL subtypes:<ref name=Ref_WMSP567/> | There are four CHL subtypes:<ref name=Ref_WMSP567/> | ||
#Nodular sclerosis CHL - ~70% of CHL. | #Nodular sclerosis CHL - ~70% of CHL. | ||
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*The subtypes prevalence is in reverse alphabetical order. | *The subtypes prevalence is in reverse alphabetical order. | ||
==Nodular lymphocyte-predominant HL== | ===Nodular lymphocyte-predominant HL=== | ||
* | Features (nodular lymphocyte-predominant Hodgkin's lymphoma): | ||
* | *''Lymphocytic & histiocytic'' cell (L&H cell)<ref name=pmid9499174>PMID: 9499174</ref> - variant of RSC: | ||
* | **Cells (relatively) small (compared to classic RSCs). | ||
**Lobulated nucleus - '''key feature'''. | |||
**Small nucleoli. | |||
Image (NLPHL): | |||
*[http://webpathology.com/image.asp?case=388&n=16 Popcorn cell (webpathology.com)]. | |||
==IHC== | ==IHC== | ||