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Difference between revisions of "High-grade prostatic intraepithelial neoplasia"
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High-grade prostatic intraepithelial neoplasia (view source)
Revision as of 18:02, 17 March 2015
, 18:02, 17 March 2015expand
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**Nucleoli present - '''key (high power) feature'''. | **Nucleoli present - '''key (high power) feature'''. | ||
**Often increased NC ratio. | **Often increased NC ratio. | ||
**Nuclear enlargement. | **Nuclear enlargement - usually subtle/appreciated at high magnification only. | ||
*Tinctorial changes of the cytoplasm - usually amphophilic (red) or basophilic (blue). | |||
Notes: | Notes: | ||
*Nucleoli should be visible with the 20x objective. | *[[Nucleoli]] should be visible with the 20x objective. | ||
**If one uses the 40x objective... one over calls. | **If one uses the 40x objective... one over calls. | ||
*May need IHC for cancer versus HGPIN. | *May need IHC for cancer versus HGPIN. | ||
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**[[PIN-like prostatic ductal adenocarcinoma]] - glands crowded. | **[[PIN-like prostatic ductal adenocarcinoma]] - glands crowded. | ||
*Benign prostate - HGPIN has nuclear changes. | *Benign prostate - HGPIN has nuclear changes. | ||
**Central zone typically has small nucleoli;<ref>{{Cite journal | last1 = Egevad | first1 = L. | title = Cytology of the central zone of the prostate. | journal = Diagn Cytopathol | volume = 28 | issue = 5 | pages = 239-44 | month = May | year = 2003 | doi = 10.1002/dc.10275 | PMID = 12722118 }}</ref> however, the glands are larger. | |||
===HGPIN architecture=== | ===HGPIN architecture=== | ||