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Difference between revisions of "High-grade astrocytoma with piloid features"
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High-grade astrocytoma with piloid features (view source)
Revision as of 13:47, 17 October 2022
, 13:47, 17 October 2022Update infobox
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Jensflorian (talk | contribs) (Update infobox) |
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{{ Infobox diagnosis | |||
| Name = {{PAGENAME}} | |||
| Image = Pilocytic astrocytoma with anaplastic features.jpg | |||
| Width = | |||
| Caption = High-grade astrocytoma with piloid features. [[H&E stain]]. | |||
| Synonyms = | |||
| Micro = | |||
| Subtypes = | |||
| LMDDx = [[astrocytoma]], [[PXA]], [[glioblastoma]] | |||
| Stains = PAS-D +ve (eosinophilic granular bodies) | |||
| IHC = GFAP +ve | |||
| EM = | |||
| Molecular = | |||
| IF = | |||
| Gross = usually cerebellar | |||
| Grossing = | |||
| Site = brain - usu. [[cerebellum]] | |||
| Assdx = | |||
| Syndromes = | |||
| Clinicalhx = | |||
| Signs = | |||
| Symptoms = | |||
| Prevalence = very rare - esp. in children | |||
| Bloodwork = | |||
| Rads = | |||
| Endoscopy = | |||
| Prognosis = poor (analog to WHO Grade III) | |||
| Other = | |||
| ClinDDx = | |||
| Tx = | |||
}} | |||
'''High-grade astrocytoma with piloid features''' is a rare [[Glioma|glial]] tumor which often requires methylation analyis to secure diagnosis. There is currently no definitive grading, but clinical behaviour suggests WHO CNS grade 3. | '''High-grade astrocytoma with piloid features''' is a rare [[Glioma|glial]] tumor which often requires methylation analyis to secure diagnosis. There is currently no definitive grading, but clinical behaviour suggests WHO CNS grade 3. | ||
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*Imaging may be similiar to [[Glioblastoma]]. | *Imaging may be similiar to [[Glioblastoma]]. | ||
*5-year OS: 50%. | *5-year OS: 50%. | ||
*De novo cases in the setting of neurofibromatosis 1 reported. | |||
*Tumors may have history of previous radiation. | |||
=Histology= | =Histology= | ||
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*Perivascular lymphocytic cuffing. | *Perivascular lymphocytic cuffing. | ||
*Necrosis may be present. | *Necrosis may be present. | ||
==Images== | |||
<gallery> | |||
Image:Pilocytic astrocytoma with anaplastic features.jpg | APA, [[FFPE]] specimen, HE (WC). | |||
Image:Pilocytic astrocytoma with anaplastic features mimicking focally a GBM.jpg | Vacular proliferations and necrosis in APA mimicking [[GBM]] (WC). | |||
</gallery> | |||
=IHC= | =IHC= | ||
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*TERT promotor mutations are rare. | *TERT promotor mutations are rare. | ||
*Absence of IDH1/2 hotspot mutation. | *Absence of IDH1/2 hotspot mutation. | ||
=Prognosis= | |||
*Poor, but better than conventional glioblastoma.<ref>{{Cite journal | last1 = Rodriguez | first1 = FJ. | last2 = Scheithauer | first2 = BW. | last3 = Burger | first3 = PC. | last4 = Jenkins | first4 = S. | last5 = Giannini | first5 = C. | title = Anaplasia in pilocytic astrocytoma predicts aggressive behavior. | journal = Am J Surg Pathol | volume = 34 | issue = 2 | pages = 147-60 | month = Feb | year = 2010 | doi = 10.1097/PAS.0b013e3181c75238 | PMID = 20061938 }}</ref> | |||
*Prognostic unfavourable paramters include: Necrosis, Mitoses and previous radiation. | |||
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[[Category:Diagnosis]] | [[Category:Diagnosis]] | ||
[[Category:Neuropathology tumours]] | |||