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Hereditary hemochromatosis (view source)
Revision as of 14:35, 29 August 2016
, 14:35, 29 August 2016→Images: Added case with cirrhosis
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*[http://path.upmc.edu/cases/case77/path.html Hemochromatosis (upmc.edu)]. | *[http://path.upmc.edu/cases/case77/path.html Hemochromatosis (upmc.edu)]. | ||
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[[File:1 Iron 1 680x512px.tif|Trichrome shows thin fibrous bands (20X).]] | |||
[[File:2 Iron 1 680x512px.tif|Iron stain shows dense iron deposition (40X).]] | |||
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[[File:3 Iron 1 680x512px.tif|At high power, a modest inflammatory infiltrate accompanies proliferating bile ductules; no piecemeal necrosis (400X)]] | |||
[[File:4 Iron 1 1360x1024px.tif|Reticulin stain with regenerative findings, cords with two nuclei thickness, hepatic acini (400X, higher pixel photo)]] | |||
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Hemochromatosis with bridging fibrosis. | |||
Trichrome shows thin fibrous bands (Row 1 Left 20X). Iron stain shows dense iron deposition (Row 1 Right 40X). At high power, a modest inflammatory infiltrate accompanies proliferating bile ductules; no piecemeal necrosis (Row 2 Left 400X). Reticulin stain with regenerative findings, cords with two nuclei thickness, hepatic acini (Row 2 right 400X, higher pixel photo). | |||
{| | |||
[[File:1 Iron 2 680x512px.tif|Fibrous bands dissect hepatocyte nodules (Row 1 Left 20X).]] | |||
[[File:2 Iron 2 680x512px.tif|Iron stain shows 4+ iron, identifiable at the lowest magnification, as well by naked eye (Row 1 Right 20X)]] | |||
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[[File:3 Iron 2 680x512px.tif|This nodule has occasionally enlarged nuclei, which should not be considered dysplasia in and of itself. Note associated relatively inflammation free band with proliferated bile ductules. (Row 2 Left 400X).]] | |||
[[File:4 Iron 2 680x512px.tif|Reticulin stain shows two cell thick regenerative cords with sinusoidal black lines lacking orientation (Row 2 Right 400X).]] | |||
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Hemochromatosis with cirrhosis.. | |||
Fibrous bands dissect hepatocyte nodules (Row 1 Left 20X). Iron stain shows 4+ iron, identifiable at the lowest magnification, as well by naked eye (Row 1 Right 20X) This nodule has occasionally enlarged nuclei, which should not be considered dysplasia in and of itself. Note associated relatively inflammation free band with proliferated bile ductules. (Row 2 Left 400X). Reticulin stain shows two cell thick regenerative cords with sinusoidal black lines lacking orientation (Row 2 Right 400X). | |||
==Stains== | ==Stains== | ||
Iron stain +ve -- '''important'''. | Iron stain +ve -- '''important'''. | ||