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[[Image:Signet_ring_cell_carcinoma_-_very_high_mag.jpg|thumb|right|200px|[[Signet ring cell carcinoma]], as may be seen in hereditary diffuse gastric cancer. [[H&E stain]].]] | |||
'''Hereditary diffuse gastric cancer''', abbreviated '''HDGC''', is an important hereditary cause of diffuse [[gastric cancer]].<ref>{{cite journal |author=Sereno M, Aguayo C, Guillén Ponce C, ''et al.'' |title=Gastric tumours in hereditary cancer syndromes: clinical features, molecular biology and strategies for prevention |journal=Clin Transl Oncol |volume=13 |issue=9 |pages=599–610 |year=2011 |month=September |pmid=21865131 |doi= |url=}}</ref> | '''Hereditary diffuse gastric cancer''', abbreviated '''HDGC''', is an important hereditary cause of diffuse [[gastric cancer]].<ref>{{cite journal |author=Sereno M, Aguayo C, Guillén Ponce C, ''et al.'' |title=Gastric tumours in hereditary cancer syndromes: clinical features, molecular biology and strategies for prevention |journal=Clin Transl Oncol |volume=13 |issue=9 |pages=599–610 |year=2011 |month=September |pmid=21865131 |doi= |url=}}</ref> | ||
It is caused by mutations in the epithelial cadherin gene (also ''E-cadherin'' and ''CDH1'').<ref name=omim137215>{{OMIM|137215}}</ref><Ref>{{OMIM|192090}}</ref> | It is caused by mutations in the epithelial cadherin gene (also ''[[E-cadherin]]'' and ''CDH1'').<ref name=omim137215>{{OMIM|137215}}</ref><Ref>{{OMIM|192090}}</ref> | ||
==General== | ==General== | ||
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==See also== | ==See also== | ||
*[[Stomach]]. | *[[Stomach]]. | ||
*[[Hereditary breast cancer]]. | |||
*[[E-cadherin]]. | |||
==References== | ==References== |
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